Fabry disease exacerbates renal interstitial fibrosis after unilateral ureteral obstruction via impaired autophagy and enhanced apoptosis

Fabry disease exacerbates renal interstitial fibrosis after unilateral ureteral obstruction via impaired autophagy and enhanced apoptosis

Background Fabry disease is a rare X-linked genetic lysosomal disorder caused by mutations in the GLA gene encoding alpha-galactosidase A. Despite some data showing that profibrotic and proinflammatory cytokines and oxidative stress could be involved in Fabry disease-related renal injury, the pathog...

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Bibliographic Details
Main Authors: Sungjin Chung, Mina Son, Yura Chae, Songhee Oh, Eun Sil Koh, Yong Kyun Kim, Seok Joon Shin, Cheol Whee Park, Sung-Chul Jung, Ho-Shik Kim
Format: Article
Language:English
Published: The Korean Society of Nephrology 2021-06-01
Series:Kidney Research and Clinical Practice
Subjects:
alpha-galactosidase
autophagy
fabry disease
fibrosis
Online Access:http://www.krcp-ksn.org/upload/pdf/j-krcp-20-264.pdf

Internet

http://www.krcp-ksn.org/upload/pdf/j-krcp-20-264.pdf

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