New Anti-Nodal Monoclonal Antibodies Targeting the Nodal Pre-Helix Loop Involved in Cripto-1 Binding

New Anti-Nodal Monoclonal Antibodies Targeting the Nodal Pre-Helix Loop Involved in Cripto-1 Binding

Nodal is a potent embryonic morphogen belonging to the TGF-β superfamily. Typically, it also binds to the ALK4/ActRIIB receptor complex in the presence of the co-receptor Cripto-1. Nodal expression is physiologically restricted to embryonic tissues and human embryonic stem cells, is absent in norma...

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Bibliographic Details
Main Authors: Annalia Focà, Luca Sanguigno, Giuseppina Focà, Luigi Strizzi, Roberta Iannitti, Rosanna Palumbo, Mary J. C. Hendrix, Antonio Leonardi, Menotti Ruvo, Annamaria Sandomenico
Format: Article
Language:English
Published: MDPI AG 2015-09-01
Series:International Journal of Molecular Sciences
Subjects:
Fab fragments
monoclonal antibody
melanoma
nodal
SPR
Online Access:http://www.mdpi.com/1422-0067/16/9/21342

Internet

http://www.mdpi.com/1422-0067/16/9/21342

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