Interplay between Cartilage and Subchondral Bone Contributing to Pathogenesis of Osteoarthritis

Osteoarthritis (OA) is a common debilitating joint disorder, affecting large sections of the population with significant disability and impaired quality of life. During OA, functional units of joints comprising cartilage and subchondral bone undergo uncontrolled catabolic and anabolic remodeling pro...

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Main Authors: Ju-Suk Nam, Sang-Soo Lee, Ashish R. Sharma, Supriya Jagga
Format: Article
Language:English
Published: MDPI AG 2013-09-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:http://www.mdpi.com/1422-0067/14/10/19805
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spelling doaj-77f7acf30ba7422a9aa9bdc20b32940d2020-11-24T22:57:08ZengMDPI AGInternational Journal of Molecular Sciences1422-00672013-09-011410198051983010.3390/ijms141019805Interplay between Cartilage and Subchondral Bone Contributing to Pathogenesis of OsteoarthritisJu-Suk NamSang-Soo LeeAshish R. SharmaSupriya JaggaOsteoarthritis (OA) is a common debilitating joint disorder, affecting large sections of the population with significant disability and impaired quality of life. During OA, functional units of joints comprising cartilage and subchondral bone undergo uncontrolled catabolic and anabolic remodeling processes to adapt to local biochemical and biological signals. Changes in cartilage and subchondral bone are not merely secondary manifestations of OA but are active components of the disease, contributing to its severity. Increased vascularization and formation of microcracks in joints during OA have suggested the facilitation of molecules from cartilage to bone and vice versa. Observations from recent studies support the view that both cartilage and subchondral bone can communicate with each other through regulation of signaling pathways for joint homeostasis under pathological conditions. In this review we have tried to summarize the current knowledge on the major signaling pathways that could control the cartilage-bone biochemical unit in joints and participate in intercellular communication between cartilage and subchondral bone during the process of OA. An understanding of molecular communication that regulates the functional behavior of chondrocytes and osteoblasts in both physiological and pathological conditions may lead to development of more effective strategies for treating OA patients.http://www.mdpi.com/1422-0067/14/10/19805osteoarthritiswingless-type (WNT)bone morphogenic protein (BMP)mitogen-activated protein kinases (MAPKs)cartilagesubchondral bone
collection DOAJ
language English
format Article
sources DOAJ
author Ju-Suk Nam
Sang-Soo Lee
Ashish R. Sharma
Supriya Jagga
spellingShingle Ju-Suk Nam
Sang-Soo Lee
Ashish R. Sharma
Supriya Jagga
Interplay between Cartilage and Subchondral Bone Contributing to Pathogenesis of Osteoarthritis
International Journal of Molecular Sciences
osteoarthritis
wingless-type (WNT)
bone morphogenic protein (BMP)
mitogen-activated protein kinases (MAPKs)
cartilage
subchondral bone
author_facet Ju-Suk Nam
Sang-Soo Lee
Ashish R. Sharma
Supriya Jagga
author_sort Ju-Suk Nam
title Interplay between Cartilage and Subchondral Bone Contributing to Pathogenesis of Osteoarthritis
title_short Interplay between Cartilage and Subchondral Bone Contributing to Pathogenesis of Osteoarthritis
title_full Interplay between Cartilage and Subchondral Bone Contributing to Pathogenesis of Osteoarthritis
title_fullStr Interplay between Cartilage and Subchondral Bone Contributing to Pathogenesis of Osteoarthritis
title_full_unstemmed Interplay between Cartilage and Subchondral Bone Contributing to Pathogenesis of Osteoarthritis
title_sort interplay between cartilage and subchondral bone contributing to pathogenesis of osteoarthritis
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1422-0067
publishDate 2013-09-01
description Osteoarthritis (OA) is a common debilitating joint disorder, affecting large sections of the population with significant disability and impaired quality of life. During OA, functional units of joints comprising cartilage and subchondral bone undergo uncontrolled catabolic and anabolic remodeling processes to adapt to local biochemical and biological signals. Changes in cartilage and subchondral bone are not merely secondary manifestations of OA but are active components of the disease, contributing to its severity. Increased vascularization and formation of microcracks in joints during OA have suggested the facilitation of molecules from cartilage to bone and vice versa. Observations from recent studies support the view that both cartilage and subchondral bone can communicate with each other through regulation of signaling pathways for joint homeostasis under pathological conditions. In this review we have tried to summarize the current knowledge on the major signaling pathways that could control the cartilage-bone biochemical unit in joints and participate in intercellular communication between cartilage and subchondral bone during the process of OA. An understanding of molecular communication that regulates the functional behavior of chondrocytes and osteoblasts in both physiological and pathological conditions may lead to development of more effective strategies for treating OA patients.
topic osteoarthritis
wingless-type (WNT)
bone morphogenic protein (BMP)
mitogen-activated protein kinases (MAPKs)
cartilage
subchondral bone
url http://www.mdpi.com/1422-0067/14/10/19805
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