Dynapenic Obesity and Prevalence of Type 2 Diabetes in Middle-Aged Japanese Men
Background: The independent and combined associations of muscle strength and obesity on the prevalence of type 2 diabetes in Japanese men remain unclear. Methods: Hand grip strength was cross-sectionally evaluated between 2011 and 2013 to assess muscle strength in 5039 male workers aged 40 to 64 ye...
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Japan Epidemiological Association
2015-11-01
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doaj-77fe33f4bda64e109379f12b283d4f622020-11-24T23:56:37ZengJapan Epidemiological AssociationJournal of Epidemiology0917-50401349-90922015-11-01251065666210.2188/jea.JE20140256Dynapenic Obesity and Prevalence of Type 2 Diabetes in Middle-Aged Japanese MenRyoko Kawakami0Graduate School of Sport Sciences, Waseda UniversityBackground: The independent and combined associations of muscle strength and obesity on the prevalence of type 2 diabetes in Japanese men remain unclear. Methods: Hand grip strength was cross-sectionally evaluated between 2011 and 2013 to assess muscle strength in 5039 male workers aged 40 to 64 years. Weight and height were measured, and overweight/obesity was defined as a body mass index ≥25 kg/m2. The prevalence of type 2 diabetes, defined as fasting plasma glucose ≥126 mg/dL and/or hemoglobin A1c ≥6.5% and/or self-reported physician-diagnosed diabetes, was evaluated. Odds ratios (OR) and 95% confidence intervals (95% CI) for the prevalence of type 2 diabetes were obtained using a logistic regression model. Results: In total, 611 participants had type 2 diabetes, and 1763 participants were overweight/obese. After adjustment for covariates, we found an inverse association between muscle strength and the prevalence of type 2 diabetes (P for trend <0.01). In addition, when the analyses were stratified by obesity status, the multivariable-adjusted OR per 2-standard-deviation increase in muscle strength was 0.64 (95% CI, 0.49–0.83) in the overweight/obese group, compared to a weaker relationship in the normal-weight group (OR 0.79 per 2-standard-deviation increase; 95% CI, 0.60–1.06). Conclusions: Dynapenia, an age-related decrease in muscle strength, is associated with increased prevalence of type 2 diabetes, and this relationship is stronger in overweight/obese middle-aged Japanese men than in normal-weight men. https://www.jstage.jst.go.jp/article/jea/25/10/25_JE20140256/_pdfmuscle strengthhand strengthbody mass indexhyperglycemiadynapenia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ryoko Kawakami |
spellingShingle |
Ryoko Kawakami Dynapenic Obesity and Prevalence of Type 2 Diabetes in Middle-Aged Japanese Men Journal of Epidemiology muscle strength hand strength body mass index hyperglycemia dynapenia |
author_facet |
Ryoko Kawakami |
author_sort |
Ryoko Kawakami |
title |
Dynapenic Obesity and Prevalence of Type 2 Diabetes in Middle-Aged Japanese Men |
title_short |
Dynapenic Obesity and Prevalence of Type 2 Diabetes in Middle-Aged Japanese Men |
title_full |
Dynapenic Obesity and Prevalence of Type 2 Diabetes in Middle-Aged Japanese Men |
title_fullStr |
Dynapenic Obesity and Prevalence of Type 2 Diabetes in Middle-Aged Japanese Men |
title_full_unstemmed |
Dynapenic Obesity and Prevalence of Type 2 Diabetes in Middle-Aged Japanese Men |
title_sort |
dynapenic obesity and prevalence of type 2 diabetes in middle-aged japanese men |
publisher |
Japan Epidemiological Association |
series |
Journal of Epidemiology |
issn |
0917-5040 1349-9092 |
publishDate |
2015-11-01 |
description |
Background: The independent and combined associations of muscle strength and obesity on the prevalence of type 2 diabetes in Japanese men remain unclear.
Methods: Hand grip strength was cross-sectionally evaluated between 2011 and 2013 to assess muscle strength in 5039 male workers aged 40 to 64 years. Weight and height were measured, and overweight/obesity was defined as a body mass index ≥25 kg/m2. The prevalence of type 2 diabetes, defined as fasting plasma glucose ≥126 mg/dL and/or hemoglobin A1c ≥6.5% and/or self-reported physician-diagnosed diabetes, was evaluated. Odds ratios (OR) and 95% confidence intervals (95% CI) for the prevalence of type 2 diabetes were obtained using a logistic regression model.
Results: In total, 611 participants had type 2 diabetes, and 1763 participants were overweight/obese. After adjustment for covariates, we found an inverse association between muscle strength and the prevalence of type 2 diabetes (P for trend <0.01). In addition, when the analyses were stratified by obesity status, the multivariable-adjusted OR per 2-standard-deviation increase in muscle strength was 0.64 (95% CI, 0.49–0.83) in the overweight/obese group, compared to a weaker relationship in the normal-weight group (OR 0.79 per 2-standard-deviation increase; 95% CI, 0.60–1.06).
Conclusions: Dynapenia, an age-related decrease in muscle strength, is associated with increased prevalence of type 2 diabetes, and this relationship is stronger in overweight/obese middle-aged Japanese men than in normal-weight men.
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topic |
muscle strength hand strength body mass index hyperglycemia dynapenia |
url |
https://www.jstage.jst.go.jp/article/jea/25/10/25_JE20140256/_pdf |
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