The opioid antagonist naltrexone decreases seizure‐like activity in genetic and chemically induced epilepsy models
Abstract Objective A significant number of epileptic patients fail to respond to available anticonvulsive medications. To find new anticonvulsive medications, we evaluated FDA‐approved drugs not known to be anticonvulsants. Using zebrafish larvae as an initial model system, we found that the opioid...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
Wiley
2021-09-01
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Series: | Epilepsia Open |
Subjects: | |
Online Access: | https://doi.org/10.1002/epi4.12512 |