The opioid antagonist naltrexone decreases seizure‐like activity in genetic and chemically induced epilepsy models

Abstract Objective A significant number of epileptic patients fail to respond to available anticonvulsive medications. To find new anticonvulsive medications, we evaluated FDA‐approved drugs not known to be anticonvulsants. Using zebrafish larvae as an initial model system, we found that the opioid...

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Bibliographic Details
Main Authors: Morgan L. Sturgeon, Rachel Langton, Shaunik Sharma, Robert A. Cornell, Joseph Glykys, Alexander G. Bassuk
Format: Article
Language:English
Published: Wiley 2021-09-01
Series:Epilepsia Open
Subjects:
Online Access:https://doi.org/10.1002/epi4.12512