Extensive recoding of dengue virus type 2 specifically reduces replication in primate cells without gain-of-function in Aedes aegypti mosquitoes.

Extensive recoding of dengue virus type 2 specifically reduces replication in primate cells without gain-of-function in Aedes aegypti mosquitoes.

Dengue virus (DENV), an arthropod-borne ("arbovirus") virus, causes a range of human maladies ranging from self-limiting dengue fever to the life-threatening dengue shock syndrome and proliferates well in two different taxa of the Animal Kingdom, mosquitoes and primates. Mosquitoes and pri...

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Bibliographic Details
Main Authors: Charles B Stauft, Sam H Shen, Yutong Song, Oleksandr Gorbatsevych, Emmanuel Asare, Bruce Futcher, Steffen Mueller, Anne Payne, Matthew Brecher, Laura Kramer, Eckard Wimmer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6128446?pdf=render

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