Ubiquitylation of the ER-Shaping Protein Lunapark via the CRL3KLHL12 Ubiquitin Ligase Complex

Ubiquitylation of the ER-Shaping Protein Lunapark via the CRL3KLHL12 Ubiquitin Ligase Complex

Summary: Cullin-RING ligases (CRLs) control key cellular processes by promoting ubiquitylation of a multitude of soluble cytosolic and nuclear proteins. Subsets of CRL complexes are recruited and activated locally at cellular membranes; however, few CRL functions and substrates at these distinct cel...

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Bibliographic Details
Main Authors: Laurensia Yuniati, Angela Lauriola, Manouk Gerritsen, Susana Abreu, Eric Ni, Chiara Tesoriero, Jacob O. Onireti, Teck Yew Low, Albert J.R. Heck, Andrea Vettori, Timothy Cardozo, Daniele Guardavaccaro
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Cell Reports
Subjects:
cullin-RING ligases
ubiquitin
endoplasmic reticulum
ER three-way junction
Lunapark
mTORC1
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720306173

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http://www.sciencedirect.com/science/article/pii/S2211124720306173

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