Article Synthesis and Trypanocidal Activity of Novel 2,4,5-Triaryl-N-Hydroxylimidazole Derivatives

Article Synthesis and Trypanocidal Activity of Novel 2,4,5-Triaryl-N-Hydroxylimidazole Derivatives

Herein, we report the design, synthesis and trypanocidal activity of some novel trisubstituted imidazole derivatives. These heterocyclic derivatives were structurally planned by exploring the concept of molecular hybridisation between two arylhydrazones derived from megazol, which has potent trypano...

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Bibliographic Details
Main Authors: Edson Ferreira da Silva, Carlos Alberto Manssour Fraga, Samir Aquino Carvalho, Maria das Graças Muller Oliveira de Henriques, Carmen Penido, Solange M. S. V. Wardell, Thadeu Estevam Moreira Maramaldo Costa, James L. Wardell, Solange Lisboa de Castro, Kelly Salomão, Ramon Borges da Silva, Vanessa Brandão Loback
Format: Article
Language:English
Published: MDPI AG 2013-03-01
Series:Molecules
Subjects:
2,4,5-triaryl-N-hydroxyimidazole
Trypanosoma cruzi
Chagas disease
trypanocidal activity
Online Access:http://www.mdpi.com/1420-3049/18/3/3445

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