Slow conformational exchange and overall rocking motion in ubiquitin protein crystals

Slow conformational exchange and overall rocking motion in ubiquitin protein crystals

X-ray crystallography is the main method for protein structure determination. Here the authors combine solid-state NMR measurements and molecular dynamics simulations and show that crystal packing alters the thermodynamics and kinetics of local conformational exchange as well as overall rocking moti...

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Bibliographic Details
Main Authors: Vilius Kurauskas, Sergei A. Izmailov, Olga N. Rogacheva, Audrey Hessel, Isabel Ayala, Joyce Woodhouse, Anastasya Shilova, Yi Xue, Tairan Yuwen, Nicolas Coquelle, Jacques-Philippe Colletier, Nikolai R. Skrynnikov, Paul Schanda
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00165-8

Internet

https://doi.org/10.1038/s41467-017-00165-8

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