Cellularity of adipose depots in six strains of genetically obese mice
Adipocyte cell size and number of three adipose depots, gonadal, subcutaneous, and retroperitoneal, were determined in several strains (aAy, aAiy, dbdb, obob, and NZO) of adult genetically obese mice, male and female, and in male gold thioglucose-treated mice. Epididymal pad cellularity was determin...
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1972-01-01
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Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520394281 |
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doaj-78dc9801e12d4d46a80ce5f5db84b74d2021-04-24T05:51:44ZengElsevierJournal of Lipid Research0022-22751972-01-01131211Cellularity of adipose depots in six strains of genetically obese miceP.R. Johnson0Jules Hirsch1The Rockefeller University, New York 10021The Rockefeller University, New York 10021Adipocyte cell size and number of three adipose depots, gonadal, subcutaneous, and retroperitoneal, were determined in several strains (aAy, aAiy, dbdb, obob, and NZO) of adult genetically obese mice, male and female, and in male gold thioglucose-treated mice. Epididymal pad cellularity was determined during development in yellow and viable yellow obese mice and their lean littermates, as well as in the NCS/R mouse. Cell number in the mouse epididymal pad in both lean and genetically obese animals is determined early in development, i.e., before weaning. Cell enlargement is the consistent and usually dominant morphological explanation for adipose depot enlargement in genetic and in gold thioglucose-induced mouse obesity. In some instances, hyperplasia accompanied the hypertrophy, occurring most often in the subcutaneous depot. Cell number in the subcutaneous pad of the obese–hyperglycemic female is four times that of the lean control and represents the most extreme case of hyperplasia observed. In fact, hyperplasia was consistently seen in the obob mouse. A classification for genetic obesity based primarily upon the cellularity characteristics of the adipose depots is proposed.http://www.sciencedirect.com/science/article/pii/S0022227520394281adipocytecell sizecell numbergold thioglucose obesity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
P.R. Johnson Jules Hirsch |
spellingShingle |
P.R. Johnson Jules Hirsch Cellularity of adipose depots in six strains of genetically obese mice Journal of Lipid Research adipocyte cell size cell number gold thioglucose obesity |
author_facet |
P.R. Johnson Jules Hirsch |
author_sort |
P.R. Johnson |
title |
Cellularity of adipose depots in six strains of genetically obese mice |
title_short |
Cellularity of adipose depots in six strains of genetically obese mice |
title_full |
Cellularity of adipose depots in six strains of genetically obese mice |
title_fullStr |
Cellularity of adipose depots in six strains of genetically obese mice |
title_full_unstemmed |
Cellularity of adipose depots in six strains of genetically obese mice |
title_sort |
cellularity of adipose depots in six strains of genetically obese mice |
publisher |
Elsevier |
series |
Journal of Lipid Research |
issn |
0022-2275 |
publishDate |
1972-01-01 |
description |
Adipocyte cell size and number of three adipose depots, gonadal, subcutaneous, and retroperitoneal, were determined in several strains (aAy, aAiy, dbdb, obob, and NZO) of adult genetically obese mice, male and female, and in male gold thioglucose-treated mice. Epididymal pad cellularity was determined during development in yellow and viable yellow obese mice and their lean littermates, as well as in the NCS/R mouse. Cell number in the mouse epididymal pad in both lean and genetically obese animals is determined early in development, i.e., before weaning. Cell enlargement is the consistent and usually dominant morphological explanation for adipose depot enlargement in genetic and in gold thioglucose-induced mouse obesity. In some instances, hyperplasia accompanied the hypertrophy, occurring most often in the subcutaneous depot. Cell number in the subcutaneous pad of the obese–hyperglycemic female is four times that of the lean control and represents the most extreme case of hyperplasia observed. In fact, hyperplasia was consistently seen in the obob mouse. A classification for genetic obesity based primarily upon the cellularity characteristics of the adipose depots is proposed. |
topic |
adipocyte cell size cell number gold thioglucose obesity |
url |
http://www.sciencedirect.com/science/article/pii/S0022227520394281 |
work_keys_str_mv |
AT prjohnson cellularityofadiposedepotsinsixstrainsofgeneticallyobesemice AT juleshirsch cellularityofadiposedepotsinsixstrainsofgeneticallyobesemice |
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