Lysine residues at the first and second KTKEGV repeats mediate α-Synuclein binding to membrane phospholipids

Lysine residues at the first and second KTKEGV repeats mediate α-Synuclein binding to membrane phospholipids

While α-Synuclein (α-Syn) is mainly detected as a cytosolic protein, a portion of it is recovered bound to membranes. It is suggested that binding to membrane phospholipids controls α-Syn structure, physiology and pathogenesis. We aimed at investigating the role, of the positive charged lysine resid...

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Bibliographic Details
Main Authors: Yonaton Zarbiv, Dganit Simhi-Haham, Eitan Israeli, Suaad Abed Elhadi, Jessica Grigoletto, Ronit Sharon
Format: Article
Language:English
Published: Elsevier 2014-10-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
α-Synuclein
KTKEGV repeat
Phospholipids
Soluble α-Syn oligomers
Aggregates
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114001491

Internet

http://www.sciencedirect.com/science/article/pii/S0969996114001491

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