Treatment of full thickness cartilage defects in human knees with Autologous Chondrocyte Transplantation

Background: Although a variety of strategies have been employed for managing articular cartilage defects in the knee, overall outcomes have not been satisfactory. An alternative option may be autologous chondrocyte transplantation (ACT). However, as this method is still under investigation, here we...

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Main Authors: Khalilallah Nazem, Ahmad Safdarian, Mehrafarin Fesharaki, Fariba Moulavi, Mahdi Motififard, Abolghasem Zarezadeh, Mahdi Shakibaei, Ebrahim Esfandiari, Mohammad Hossin Nasr-Esfahani
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2011-01-01
Series:Journal of Research in Medical Sciences
Subjects:
Online Access:http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2011;volume=16;issue=7;spage=855;epage=861;aulast=Nazem
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spelling doaj-79384397c27f41a1921da97d4a93113c2020-11-24T22:23:11ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362011-01-01167855861Treatment of full thickness cartilage defects in human knees with Autologous Chondrocyte TransplantationKhalilallah NazemAhmad SafdarianMehrafarin FesharakiFariba MoulaviMahdi MotififardAbolghasem ZarezadehMahdi ShakibaeiEbrahim EsfandiariMohammad Hossin Nasr-EsfahaniBackground: Although a variety of strategies have been employed for managing articular cartilage defects in the knee, overall outcomes have not been satisfactory. An alternative option may be autologous chondrocyte transplantation (ACT). However, as this method is still under investigation, here we assessed the efficacy of ACT for human knee defect cartilage repair. Methods: In a randomized clinical trial study, eleven patients (mean age 31.09 years) were enrolled in the study with full thickness cartilage defects in the knee. Arthroscopically, healthy cartilage was obtained, chondrocytes expanded for 2-3 weeks and ACT performed. Clinical status was evaluated before ACT, 6 and 12 months after ACT using the Brittberg-Peterson functional assessment and modified Cincinnati rating score. Magnetic resonance imaging (MRI) findings were evaluated based on the scoring systems used by Sally Roberts and by Henderson. Results: Modified Cincinnati rating indicated significant improvement of clinical score before ACT compared to 6 (p = 0.000) and 12 (p = 0.000) months after ACT (from 2.73 before ACT to 7.27, 8.36 and 9.5 at 6, 12, and 48 months after ACT, respectively). Brittberg-Peterson functional assessment indicated a decline from 79.27 to 25.82 and 19.27 at 6 and 12 months post ACT. Further, statistical test demonstrated significant differences 6, 12 and 48 months post ACT (p = 0.007). Evaluation of MRI revealed a score of 6.5 for Henderson criteria and a score of 2.5 for Robert criteria. Conclusions: Our study demonstrated that ACT of the knee provides an excellent treatment for full thickness cartilage defects with outstanding clinical and radiological outcomes.http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2011;volume=16;issue=7;spage=855;epage=861;aulast=NazemArticular CartilageFull Thickness Cartilage DefectAutologus Chondrocyte TransplantationKnee
collection DOAJ
language English
format Article
sources DOAJ
author Khalilallah Nazem
Ahmad Safdarian
Mehrafarin Fesharaki
Fariba Moulavi
Mahdi Motififard
Abolghasem Zarezadeh
Mahdi Shakibaei
Ebrahim Esfandiari
Mohammad Hossin Nasr-Esfahani
spellingShingle Khalilallah Nazem
Ahmad Safdarian
Mehrafarin Fesharaki
Fariba Moulavi
Mahdi Motififard
Abolghasem Zarezadeh
Mahdi Shakibaei
Ebrahim Esfandiari
Mohammad Hossin Nasr-Esfahani
Treatment of full thickness cartilage defects in human knees with Autologous Chondrocyte Transplantation
Journal of Research in Medical Sciences
Articular Cartilage
Full Thickness Cartilage Defect
Autologus Chondrocyte Transplantation
Knee
author_facet Khalilallah Nazem
Ahmad Safdarian
Mehrafarin Fesharaki
Fariba Moulavi
Mahdi Motififard
Abolghasem Zarezadeh
Mahdi Shakibaei
Ebrahim Esfandiari
Mohammad Hossin Nasr-Esfahani
author_sort Khalilallah Nazem
title Treatment of full thickness cartilage defects in human knees with Autologous Chondrocyte Transplantation
title_short Treatment of full thickness cartilage defects in human knees with Autologous Chondrocyte Transplantation
title_full Treatment of full thickness cartilage defects in human knees with Autologous Chondrocyte Transplantation
title_fullStr Treatment of full thickness cartilage defects in human knees with Autologous Chondrocyte Transplantation
title_full_unstemmed Treatment of full thickness cartilage defects in human knees with Autologous Chondrocyte Transplantation
title_sort treatment of full thickness cartilage defects in human knees with autologous chondrocyte transplantation
publisher Wolters Kluwer Medknow Publications
series Journal of Research in Medical Sciences
issn 1735-1995
1735-7136
publishDate 2011-01-01
description Background: Although a variety of strategies have been employed for managing articular cartilage defects in the knee, overall outcomes have not been satisfactory. An alternative option may be autologous chondrocyte transplantation (ACT). However, as this method is still under investigation, here we assessed the efficacy of ACT for human knee defect cartilage repair. Methods: In a randomized clinical trial study, eleven patients (mean age 31.09 years) were enrolled in the study with full thickness cartilage defects in the knee. Arthroscopically, healthy cartilage was obtained, chondrocytes expanded for 2-3 weeks and ACT performed. Clinical status was evaluated before ACT, 6 and 12 months after ACT using the Brittberg-Peterson functional assessment and modified Cincinnati rating score. Magnetic resonance imaging (MRI) findings were evaluated based on the scoring systems used by Sally Roberts and by Henderson. Results: Modified Cincinnati rating indicated significant improvement of clinical score before ACT compared to 6 (p = 0.000) and 12 (p = 0.000) months after ACT (from 2.73 before ACT to 7.27, 8.36 and 9.5 at 6, 12, and 48 months after ACT, respectively). Brittberg-Peterson functional assessment indicated a decline from 79.27 to 25.82 and 19.27 at 6 and 12 months post ACT. Further, statistical test demonstrated significant differences 6, 12 and 48 months post ACT (p = 0.007). Evaluation of MRI revealed a score of 6.5 for Henderson criteria and a score of 2.5 for Robert criteria. Conclusions: Our study demonstrated that ACT of the knee provides an excellent treatment for full thickness cartilage defects with outstanding clinical and radiological outcomes.
topic Articular Cartilage
Full Thickness Cartilage Defect
Autologus Chondrocyte Transplantation
Knee
url http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2011;volume=16;issue=7;spage=855;epage=861;aulast=Nazem
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