TOPK promotes metastasis of esophageal squamous cell carcinoma by activating the Src/GSK3β/STAT3 signaling pathway via γ-catenin

TOPK promotes metastasis of esophageal squamous cell carcinoma by activating the Src/GSK3β/STAT3 signaling pathway via γ-catenin

Abstract Background Esophageal squamous cell carcinoma (ESCC) is a fatal disease with poor prognosis. The predominant reason for ESCC-related death is distal metastasis. A comprehensive understanding of the molecular mechanism underlying metastasis is needed for improving patient prognosis. T-LAK ce...

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Bibliographic Details
Main Authors: Yanan Jiang, Jing Zhang, Jimin Zhao, Zhenzhen Li, Hanyong Chen, Yan Qiao, Xinhuan Chen, Kangdong Liu, Ziming Dong
Format: Article
Language:English
Published: BMC 2019-12-01
Series:BMC Cancer
Subjects:
Esophageal squamous cell carcinoma
TOPK
Tumor metastasis
Src/GSK3β/STAT3
γ-Catenin
Online Access:https://doi.org/10.1186/s12885-019-6453-z

Internet

https://doi.org/10.1186/s12885-019-6453-z

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