RNA Binding Proteins Control Transdifferentiation of Hepatic Stellate Cells into Myofibroblasts

RNA Binding Proteins Control Transdifferentiation of Hepatic Stellate Cells into Myofibroblasts

Background/Aims: Myofibroblasts (MF) derived from quiescent nonfibrogenic hepatic stellate cells (HSC) are the major sources of fibrous matrix in cirrhosis. Because many factors interact to regulate expansion and regression of MF-HSC populations, efforts to prevent cirrhosis by targeting any one fac...

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Bibliographic Details
Main Authors: Sihyung Wang, Youngmi Jung, Jeongeun Hyun, Matthew Friedersdorf, Seh-Hoon Oh, Jieun Kim, Richard T. Premont, Jack D. Keene, Anna Mae Diehl
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
IMP3
Cirrhosis
RNA binding protein
Insulin-like growth factor 2 binding protein 3
Mesenchymal stem cells (MSCs)
Epithelial-mesenchymal transition (EMT)
Transforming growth factor beta (TGF-β)
MicroRNA (miRNA)
Online Access:https://www.karger.com/Article/FullText/491987

Internet

https://www.karger.com/Article/FullText/491987

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