Human tumor-derived exosomes (TEX) regulate Treg functions via cell surface signaling rather than uptake mechanisms

Human tumor-derived exosomes (TEX) regulate Treg functions via cell surface signaling rather than uptake mechanisms

Tumor-derived exosomes (TEX) are ubiquitously present in the tumor microenvironment and plasma of cancer patients. TEX carry a cargo of multiple stimulatory and inhibitory molecules and deliver them to recipient cells, serving as a communication network for the tumor. The mechanisms TEX use for deli...

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Bibliographic Details
Main Authors: Laurent Muller, Patricia Simms, Chang-Sook Hong, Michael I. Nishimura, Edwin K. Jackson, Simon C. Watkins, Theresa L. Whiteside
Format: Article
Language:English
Published: Taylor & Francis Group 2017-08-01
Series:OncoImmunology
Subjects:
ca2+ flux
exosome uptake
regulatory t cells
t cell subsets
tumor-derived exosomes
Online Access:http://dx.doi.org/10.1080/2162402X.2016.1261243

Internet

http://dx.doi.org/10.1080/2162402X.2016.1261243

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