TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication

TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication

The faithful segregation of eukaryotic chromosomes in mitosis requires that the genome be duplicated completely prior to anaphase. However, cells with large genomes sometimes fail to complete replication during interphase and instead enter mitosis with regions of incompletely replicated DNA. These r...

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Bibliographic Details
Main Authors: Remi Sonneville, Rahul Bhowmick, Saskia Hoffmann, Niels Mailand, Ian D Hickson, Karim Labib
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-09-01
Series:eLife
Subjects:
DNA replication
genome stability
ubiquitin ligase
TRAIP
mitosis
fragile site
Online Access:https://elifesciences.org/articles/48686

Internet

https://elifesciences.org/articles/48686

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