Simvastatin improves survival and reduces leukocyte recruitment and hepatocyte apoptosis in endotoxin-induced liver injury

Simvastatin improves survival and reduces leukocyte recruitment and hepatocyte apoptosis in endotoxin-induced liver injury

BACKGROUND. Endotoxemia provokes excessive host response to bacteria or microbial compounds, resulting in systemic inflammation, organ injury and mortality. Aim: This study examined the effects of simvastatin on survival and liver injury in endotoxic shock in a rat model of endotoxemia. METHODS. Mal...

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Bibliographic Details
Main Authors: Nežić Lana, Amidžić Lj., Jaćević V., Dobrić S., Škrbić R., Stojiljković M.P., Komić J., Stoisavljević-Šatara S.
Format: Article
Language:English
Published: Medical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of Medicine 2011-01-01
Series:Scripta Medica
Subjects:
simvastatin
liver injury
endotoxin
inflammation
apoptosis
Online Access:https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2011/2490-33291101007N.pdf

Internet

https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2011/2490-33291101007N.pdf

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