EP300 knockdown reduces cancer stem cell phenotype, tumor growth and metastasis in triple negative breast cancer

EP300 knockdown reduces cancer stem cell phenotype, tumor growth and metastasis in triple negative breast cancer

Abstract Background Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype with basal features, lacking the expression of receptors targeted successfully in other breast cancer subtypes. Treatment response to adjuvant and neoadjuvant chemotherapy is often short-lived and metasta...

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Bibliographic Details
Main Authors: Alexander Ring, Pushpinder Kaur, Julie E. Lang
Format: Article
Language:English
Published: BMC 2020-11-01
Series:BMC Cancer
Subjects:
Triple negative breast cancer (TNBC)
Basal-like BC
E1A-associated protein p300 (EP300)
Cancer stem cells (CSC)
ATP-binding cassette super-family G member 2 (ABCG2)/breast Cancer resistance protein (BCRP)
Metastasis
Online Access:http://link.springer.com/article/10.1186/s12885-020-07573-y

Internet

http://link.springer.com/article/10.1186/s12885-020-07573-y

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