Influenza a virus antagonizes type I and type II interferon responses via SOCS1-dependent ubiquitination and degradation of JAK1

Influenza a virus antagonizes type I and type II interferon responses via SOCS1-dependent ubiquitination and degradation of JAK1

Abstract Background Although influenza A virus (IAV) employs diverse strategies to evade IFN responses by inhibiting the synthesis of IFN, how IAV regulates signaling downstream of IFN is incompletely understood. Methods In this study, we used Western blot-based protein analysis coupled with RT-qPCR...

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Bibliographic Details
Main Authors: Yinping Du, Fan Yang, Qiuxia Wang, Nuo Xu, Yizhang Xie, Sujuan Chen, Tao Qin, Daxin Peng
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Virology Journal
Subjects:
IAV
JAK1
IFN
SOCS1
Degradation
Online Access:http://link.springer.com/article/10.1186/s12985-020-01348-4

Internet

http://link.springer.com/article/10.1186/s12985-020-01348-4

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