Intrinsic Type 1 Interferon (IFN1) Profile of Uncultured Human Bone Marrow CD45<sup>low</sup>CD271<sup>+</sup> Multipotential Stromal Cells (BM-MSCs): The Impact of Donor Age, Culture Expansion and IFNα and IFNβ Stimulation

Intrinsic Type 1 Interferon (IFN1) Profile of Uncultured Human Bone Marrow CD45<sup>low</sup>CD271<sup>+</sup> Multipotential Stromal Cells (BM-MSCs): The Impact of Donor Age, Culture Expansion and IFNα and IFNβ Stimulation

Skeletal aging is associated with reduced proliferative potential of bone marrow (BM) multipotential stromal cells (MSCs). Recent data suggest the involvement of type 1 interferon (IFN1) signalling in hematopoietic stem cell (HSC) senescence. Considering that BM-HSCs and BM-MSCs share the same BM ni...

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Bibliographic Details
Main Authors: Payal Ganguly, Agata N. Burska, Charlotte L.M. Davis, Jehan J. El-Jawhari, Peter V. Giannoudis, Elena A. Jones
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Biomedicines
Subjects:
aging
mesenchymal stromal cells
bone marrow
type 1 interferon
senescence
Online Access:https://www.mdpi.com/2227-9059/8/7/214

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https://www.mdpi.com/2227-9059/8/7/214

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