Brain endothelial cell TRPA1 channels initiate neurovascular coupling

Brain endothelial cell TRPA1 channels initiate neurovascular coupling

Cerebral blood flow is dynamically regulated by neurovascular coupling to meet the dynamic metabolic demands of the brain. We hypothesized that TRPA1 channels in capillary endothelial cells are stimulated by neuronal activity and instigate a propagating retrograde signal that dilates upstream parenc...

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Bibliographic Details
Main Authors: Pratish Thakore, Michael G Alvarado, Sher Ali, Amreen Mughal, Paulo W Pires, Evan Yamasaki, Harry AT Pritchard, Brant E Isakson, Cam Ha T Tran, Scott Earley
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-02-01
Series:eLife
Subjects:
TRPA1 channels
panx1 channels
purinergic signaling
conducted vasodilation
neurovascular coupling
Online Access:https://elifesciences.org/articles/63040

Internet

https://elifesciences.org/articles/63040

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