Efficacy of Single-Dose Ivermectin on Virologic and Clinical Recovery in COVID-19: A Randomized Controlled Trial
Background: Coronavirus disease 2019 (COVID-19) pandemic mounts an ever increasing challenge on healthcare resources. Ivermectin shows promise in in vitro studies on coronavirus, but there are few prospective trials on currently approved dosage recommendation for the treatment of COVID-19. Aims: To...
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doaj-7b3a86b5d28a486fa6474220565ce2602021-09-08T03:51:30ZengWolters Kluwer Medknow PublicationsMAMC Journal of Medical Sciences2394-74382021-01-017210911410.4103/mamcjms.mamcjms_77_21Efficacy of Single-Dose Ivermectin on Virologic and Clinical Recovery in COVID-19: A Randomized Controlled TrialRomit SaxenaMuthu RajanagamUrmila JhambVikas ManchandaSonal SaxenaPallaviBackground: Coronavirus disease 2019 (COVID-19) pandemic mounts an ever increasing challenge on healthcare resources. Ivermectin shows promise in in vitro studies on coronavirus, but there are few prospective trials on currently approved dosage recommendation for the treatment of COVID-19. Aims: To study the virologic and clinical recovery after single-dose ivermectin, given within first 5 days of symptom onset. Settings and design: Prospective, open-labeled, randomized controlled trial. Patients were recruited in between August 30, 2020, and November 6, 2020, at a single referral center for patients with COVID. Materials and methods: The study participants included patients presenting with severe acute respiratory syndrome coronavirus 2 infection. The patients were randomized to receive a single-dose ivermectin, 0.2 mg/kg in the treatment group (TG). Both groups [TG and control group (CG)], continued to receive standard treatment. Results: The recruited cohort was comparable in the two arms of the study, except age and height. There was no statistically significant difference in virologic clearance between the two arms (percentage COVID positive day 7: TG: 34.2% vs. CG: 52.6%, P = 0.165). Conclusion: Our study shows that after administration of single dose of currently approved doses of ivermectin (0.2 mg/kg), there does not exist a significant virologic or clinical recovery in COVID-19 disease.http://www.mamcjms.in/article.asp?issn=2394-7438;year=2021;volume=7;issue=2;spage=109;epage=114;aulast=Saxenacoronavirus diseaserandomized controlled trialrt-pcr |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Romit Saxena Muthu Rajanagam Urmila Jhamb Vikas Manchanda Sonal Saxena Pallavi |
spellingShingle |
Romit Saxena Muthu Rajanagam Urmila Jhamb Vikas Manchanda Sonal Saxena Pallavi Efficacy of Single-Dose Ivermectin on Virologic and Clinical Recovery in COVID-19: A Randomized Controlled Trial MAMC Journal of Medical Sciences coronavirus disease randomized controlled trial rt-pcr |
author_facet |
Romit Saxena Muthu Rajanagam Urmila Jhamb Vikas Manchanda Sonal Saxena Pallavi |
author_sort |
Romit Saxena |
title |
Efficacy of Single-Dose Ivermectin on Virologic and Clinical Recovery in COVID-19: A Randomized Controlled Trial |
title_short |
Efficacy of Single-Dose Ivermectin on Virologic and Clinical Recovery in COVID-19: A Randomized Controlled Trial |
title_full |
Efficacy of Single-Dose Ivermectin on Virologic and Clinical Recovery in COVID-19: A Randomized Controlled Trial |
title_fullStr |
Efficacy of Single-Dose Ivermectin on Virologic and Clinical Recovery in COVID-19: A Randomized Controlled Trial |
title_full_unstemmed |
Efficacy of Single-Dose Ivermectin on Virologic and Clinical Recovery in COVID-19: A Randomized Controlled Trial |
title_sort |
efficacy of single-dose ivermectin on virologic and clinical recovery in covid-19: a randomized controlled trial |
publisher |
Wolters Kluwer Medknow Publications |
series |
MAMC Journal of Medical Sciences |
issn |
2394-7438 |
publishDate |
2021-01-01 |
description |
Background: Coronavirus disease 2019 (COVID-19) pandemic mounts an ever increasing challenge on healthcare resources. Ivermectin shows promise in in vitro studies on coronavirus, but there are few prospective trials on currently approved dosage recommendation for the treatment of COVID-19. Aims: To study the virologic and clinical recovery after single-dose ivermectin, given within first 5 days of symptom onset. Settings and design: Prospective, open-labeled, randomized controlled trial. Patients were recruited in between August 30, 2020, and November 6, 2020, at a single referral center for patients with COVID. Materials and methods: The study participants included patients presenting with severe acute respiratory syndrome coronavirus 2 infection. The patients were randomized to receive a single-dose ivermectin, 0.2 mg/kg in the treatment group (TG). Both groups [TG and control group (CG)], continued to receive standard treatment. Results: The recruited cohort was comparable in the two arms of the study, except age and height. There was no statistically significant difference in virologic clearance between the two arms (percentage COVID positive day 7: TG: 34.2% vs. CG: 52.6%, P = 0.165). Conclusion: Our study shows that after administration of single dose of currently approved doses of ivermectin (0.2 mg/kg), there does not exist a significant virologic or clinical recovery in COVID-19 disease. |
topic |
coronavirus disease randomized controlled trial rt-pcr |
url |
http://www.mamcjms.in/article.asp?issn=2394-7438;year=2021;volume=7;issue=2;spage=109;epage=114;aulast=Saxena |
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