Clinicopathological Risk Factors for Contralateral Lymph Node Metastases in Intraoral Squamous Cell Carcinoma: A Study of 331 Cases

The current study aimed to examine the effects of clinicopathological factors, including the region, midline involvement, T classification, histological grade, and differentiation of the tumor on the rate of contralateral lymph node metastasis for oral squamous cell carcinoma and to assess their eff...

Full description

Bibliographic Details
Main Authors: Christian Flörke, Aydin Gülses, Christina-Randi Altmann, Jörg Wiltfang, Henning Wieker, Hendrik Naujokat
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Current Oncology
Subjects:
Online Access:https://www.mdpi.com/1718-7729/28/3/175
id doaj-7c13092aea3642c5a604ddc7c5eb59c0
record_format Article
spelling doaj-7c13092aea3642c5a604ddc7c5eb59c02021-09-20T10:10:34ZengMDPI AGCurrent Oncology1198-00521718-77292021-05-01281751886189810.3390/curroncol28030175Clinicopathological Risk Factors for Contralateral Lymph Node Metastases in Intraoral Squamous Cell Carcinoma: A Study of 331 CasesChristian Flörke0Aydin Gülses1Christina-Randi Altmann2Jörg Wiltfang3Henning Wieker4Hendrik Naujokat5Department of Oral and Maxillofacial Surgery, Christian Albrechts University, UKSH, 24105 Kiel, GermanyDepartment of Oral and Maxillofacial Surgery, Christian Albrechts University, UKSH, 24105 Kiel, GermanyDepartment of Oral and Maxillofacial Surgery, Christian Albrechts University, UKSH, 24105 Kiel, GermanyDepartment of Oral and Maxillofacial Surgery, Christian Albrechts University, UKSH, 24105 Kiel, GermanyDepartment of Oral and Maxillofacial Surgery, Christian Albrechts University, UKSH, 24105 Kiel, GermanyDepartment of Oral and Maxillofacial Surgery, Christian Albrechts University, UKSH, 24105 Kiel, GermanyThe current study aimed to examine the effects of clinicopathological factors, including the region, midline involvement, T classification, histological grade, and differentiation of the tumor on the rate of contralateral lymph node metastasis for oral squamous cell carcinoma and to assess their effects on survival rates. A total of 331 patients with intraoral squamous cell carcinomas were included. The influence of tumor location, T status, midline involvement, tumor grading, and the infiltration depth of the tumor on the pattern of metastasis was evaluated. Additionally, the effect of contralateral metastases on the prognosis was examined. Metastases of the contralateral side occurred most frequently in squamous cell carcinomas of the palate and floor of the mouth. Furthermore, tumors with a high T status resulted in significantly higher rates of contralateral metastases. Similarly, the midline involvement, tumor grading, existing ipsilateral metastases, and the infiltration depth of the tumor had a highly significant influence on the development of lymph node metastases on the opposite side. Oral squamous cell carcinomas require a patient-specific decision. There is an ongoing need for further prospective studies to confirm the validity of the prognostic factors described herein.https://www.mdpi.com/1718-7729/28/3/175squamous cell carcinomaintraoralmetastasiscontralateral
collection DOAJ
language English
format Article
sources DOAJ
author Christian Flörke
Aydin Gülses
Christina-Randi Altmann
Jörg Wiltfang
Henning Wieker
Hendrik Naujokat
spellingShingle Christian Flörke
Aydin Gülses
Christina-Randi Altmann
Jörg Wiltfang
Henning Wieker
Hendrik Naujokat
Clinicopathological Risk Factors for Contralateral Lymph Node Metastases in Intraoral Squamous Cell Carcinoma: A Study of 331 Cases
Current Oncology
squamous cell carcinoma
intraoral
metastasis
contralateral
author_facet Christian Flörke
Aydin Gülses
Christina-Randi Altmann
Jörg Wiltfang
Henning Wieker
Hendrik Naujokat
author_sort Christian Flörke
title Clinicopathological Risk Factors for Contralateral Lymph Node Metastases in Intraoral Squamous Cell Carcinoma: A Study of 331 Cases
title_short Clinicopathological Risk Factors for Contralateral Lymph Node Metastases in Intraoral Squamous Cell Carcinoma: A Study of 331 Cases
title_full Clinicopathological Risk Factors for Contralateral Lymph Node Metastases in Intraoral Squamous Cell Carcinoma: A Study of 331 Cases
title_fullStr Clinicopathological Risk Factors for Contralateral Lymph Node Metastases in Intraoral Squamous Cell Carcinoma: A Study of 331 Cases
title_full_unstemmed Clinicopathological Risk Factors for Contralateral Lymph Node Metastases in Intraoral Squamous Cell Carcinoma: A Study of 331 Cases
title_sort clinicopathological risk factors for contralateral lymph node metastases in intraoral squamous cell carcinoma: a study of 331 cases
publisher MDPI AG
series Current Oncology
issn 1198-0052
1718-7729
publishDate 2021-05-01
description The current study aimed to examine the effects of clinicopathological factors, including the region, midline involvement, T classification, histological grade, and differentiation of the tumor on the rate of contralateral lymph node metastasis for oral squamous cell carcinoma and to assess their effects on survival rates. A total of 331 patients with intraoral squamous cell carcinomas were included. The influence of tumor location, T status, midline involvement, tumor grading, and the infiltration depth of the tumor on the pattern of metastasis was evaluated. Additionally, the effect of contralateral metastases on the prognosis was examined. Metastases of the contralateral side occurred most frequently in squamous cell carcinomas of the palate and floor of the mouth. Furthermore, tumors with a high T status resulted in significantly higher rates of contralateral metastases. Similarly, the midline involvement, tumor grading, existing ipsilateral metastases, and the infiltration depth of the tumor had a highly significant influence on the development of lymph node metastases on the opposite side. Oral squamous cell carcinomas require a patient-specific decision. There is an ongoing need for further prospective studies to confirm the validity of the prognostic factors described herein.
topic squamous cell carcinoma
intraoral
metastasis
contralateral
url https://www.mdpi.com/1718-7729/28/3/175
work_keys_str_mv AT christianflorke clinicopathologicalriskfactorsforcontralaterallymphnodemetastasesinintraoralsquamouscellcarcinomaastudyof331cases
AT aydingulses clinicopathologicalriskfactorsforcontralaterallymphnodemetastasesinintraoralsquamouscellcarcinomaastudyof331cases
AT christinarandialtmann clinicopathologicalriskfactorsforcontralaterallymphnodemetastasesinintraoralsquamouscellcarcinomaastudyof331cases
AT jorgwiltfang clinicopathologicalriskfactorsforcontralaterallymphnodemetastasesinintraoralsquamouscellcarcinomaastudyof331cases
AT henningwieker clinicopathologicalriskfactorsforcontralaterallymphnodemetastasesinintraoralsquamouscellcarcinomaastudyof331cases
AT hendriknaujokat clinicopathologicalriskfactorsforcontralaterallymphnodemetastasesinintraoralsquamouscellcarcinomaastudyof331cases
_version_ 1717374600842575872