STAT3 but Not HIF-1α Is Important in Mediating Hypoxia-Induced Chemoresistance in MDA-MB-231, a Triple Negative Breast Cancer Cell Line

STAT3 but Not HIF-1α Is Important in Mediating Hypoxia-Induced Chemoresistance in MDA-MB-231, a Triple Negative Breast Cancer Cell Line

Hypoxia-induced chemoresistance (HICR) is a well-recognized phenomenon, and in many experimental models, hypoxia inducible factor-1α (HIF-1α) is believed to be a key player. We aimed to better understand the mechanism underlying HICR in a triple negative breast cancer cell line, MDA-MB-231, with a f...

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Bibliographic Details
Main Authors: Hoda Soleymani Abyaneh, Nidhi Gupta, Aneta Radziwon-Balicka, Paul Jurasz, John Seubert, Raymond Lai, Afsaneh Lavasanifar
Format: Article
Language:English
Published: MDPI AG 2017-10-01
Series:Cancers
Subjects:
hypoxia-induced chemoresistance
HIF-1α
STAT3
cisplatin
cancer stemness
Online Access:https://www.mdpi.com/2072-6694/9/10/137

Internet

https://www.mdpi.com/2072-6694/9/10/137

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