Metformin and Androgen Receptor-Axis-Targeted (ARAT) Agents Induce Two PARP-1-Dependent Cell Death Pathways in Androgen-Sensitive Human Prostate Cancer Cells

Metformin and Androgen Receptor-Axis-Targeted (ARAT) Agents Induce Two PARP-1-Dependent Cell Death Pathways in Androgen-Sensitive Human Prostate Cancer Cells

We explored whether the anti-prostate cancer (PC) activity of the androgen receptor-axis-targeted agents (ARATs) abiraterone and enzalutamide is enhanced by metformin. Using complementary biological and molecular approaches, we determined the associated underlying mechanisms in pre-clinical androgen...

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Bibliographic Details
Main Authors: Yi Xie, Linbo Wang, Mohammad A. Khan, Anne W. Hamburger, Wei Guang, Antonino Passaniti, Kashif Munir, Douglas D. Ross, Michael Dean, Arif Hussain
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cancers
Subjects:
prostate cancer
metformin
ARAT
PARP-1
poly(ADP-ribose) (PAR)
lysosome
Online Access:https://www.mdpi.com/2072-6694/13/4/633

Internet

https://www.mdpi.com/2072-6694/13/4/633

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