The Zinc-Dependent Protease Activity of the Botulinum Neurotoxins

The Zinc-Dependent Protease Activity of the Botulinum Neurotoxins

The botulinum neurotoxins (BoNT, serotypes A-G) are some of the most toxic proteins known and are the causative agents of botulism. Following exposure, the neurotoxin binds and enters peripheral cholinergic nerve endings and specifically and selectively cleaves one or more SNARE proteins to produce...

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Bibliographic Details
Main Authors: Frank J. Lebeda, Regina Z. Cer, Uma Mudunuri, Robert Stephens, Bal Ram Singh, Michael Adler
Format: Article
Language:English
Published: MDPI AG 2010-05-01
Series:Toxins
Subjects:
catalysis
energy
kcat
Km
superactivation
Online Access:http://www.mdpi.com/2072-6651/2/5/978/

Internet

http://www.mdpi.com/2072-6651/2/5/978/

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