Prevalence of sarcopenia in community-dwelling older adults using the updated EWGSOP2 definition according to kidney function and albuminuria

Abstract Background Loss of muscle mass and function may be more pronounced in older adults with chronic kidney disease (CKD) and with albuminuria. Thus, we investigated the prevalence of sarcopenia among community-dwelling older adults according to kidney function and grade of albuminuria. We also...

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Main Authors: Rafael Moreno-Gonzalez, Xavier Corbella, Francesco Mattace-Raso, Lisanne Tap, Cornel Sieber, Ellen Freiberger, Tomasz Kostka, Agnieszka Guligowska, Itshak Melzer, Yehudit Melzer, Axel C. Carlsson, Johan Ärnlöv, Regina Roller-Wirnsberger, Gerhard Wirnsberger, Pedro Gil, Sara Lainez Martinez, Paolo Fabbietti, Andrea Corsonello, Fabrizia Lattanzio, Francesc Formiga, on behalf of SCOPE investigators
Format: Article
Language:English
Published: BMC 2020-10-01
Series:BMC Geriatrics
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12877-020-01700-x
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author Rafael Moreno-Gonzalez
Xavier Corbella
Francesco Mattace-Raso
Lisanne Tap
Cornel Sieber
Ellen Freiberger
Tomasz Kostka
Agnieszka Guligowska
Itshak Melzer
Yehudit Melzer
Axel C. Carlsson
Johan Ärnlöv
Regina Roller-Wirnsberger
Gerhard Wirnsberger
Pedro Gil
Sara Lainez Martinez
Paolo Fabbietti
Andrea Corsonello
Fabrizia Lattanzio
Francesc Formiga
on behalf of SCOPE investigators
spellingShingle Rafael Moreno-Gonzalez
Xavier Corbella
Francesco Mattace-Raso
Lisanne Tap
Cornel Sieber
Ellen Freiberger
Tomasz Kostka
Agnieszka Guligowska
Itshak Melzer
Yehudit Melzer
Axel C. Carlsson
Johan Ärnlöv
Regina Roller-Wirnsberger
Gerhard Wirnsberger
Pedro Gil
Sara Lainez Martinez
Paolo Fabbietti
Andrea Corsonello
Fabrizia Lattanzio
Francesc Formiga
on behalf of SCOPE investigators
Prevalence of sarcopenia in community-dwelling older adults using the updated EWGSOP2 definition according to kidney function and albuminuria
BMC Geriatrics
Older adults
Sarcopenia
Chronic kidney disease
Albuminuria
EWGSOP2
Estimated glomerular filtration rate
author_facet Rafael Moreno-Gonzalez
Xavier Corbella
Francesco Mattace-Raso
Lisanne Tap
Cornel Sieber
Ellen Freiberger
Tomasz Kostka
Agnieszka Guligowska
Itshak Melzer
Yehudit Melzer
Axel C. Carlsson
Johan Ärnlöv
Regina Roller-Wirnsberger
Gerhard Wirnsberger
Pedro Gil
Sara Lainez Martinez
Paolo Fabbietti
Andrea Corsonello
Fabrizia Lattanzio
Francesc Formiga
on behalf of SCOPE investigators
author_sort Rafael Moreno-Gonzalez
title Prevalence of sarcopenia in community-dwelling older adults using the updated EWGSOP2 definition according to kidney function and albuminuria
title_short Prevalence of sarcopenia in community-dwelling older adults using the updated EWGSOP2 definition according to kidney function and albuminuria
title_full Prevalence of sarcopenia in community-dwelling older adults using the updated EWGSOP2 definition according to kidney function and albuminuria
title_fullStr Prevalence of sarcopenia in community-dwelling older adults using the updated EWGSOP2 definition according to kidney function and albuminuria
title_full_unstemmed Prevalence of sarcopenia in community-dwelling older adults using the updated EWGSOP2 definition according to kidney function and albuminuria
title_sort prevalence of sarcopenia in community-dwelling older adults using the updated ewgsop2 definition according to kidney function and albuminuria
publisher BMC
series BMC Geriatrics
issn 1471-2318
publishDate 2020-10-01
description Abstract Background Loss of muscle mass and function may be more pronounced in older adults with chronic kidney disease (CKD) and with albuminuria. Thus, we investigated the prevalence of sarcopenia among community-dwelling older adults according to kidney function and grade of albuminuria. We also explored differences in the prevalence of sarcopenia according to three different equations for the estimation of glomerular filtration rate (eGFR). Methods A cross-sectional analysis of 1420 community-dwelling older adults (≥75 years old) included in the SCOPE study, a multicenter prospective cohort study, was conducted. Comprehensive geriatric assessment including short physical performance battery (SPPB), handgrip strength test and bioelectrical impedance analysis (BIA) was performed. Sarcopenia was defined using the updated criteria of the European Working Group on Sarcopenia in Older People (EWGSOP2). eGFR was calculated using Berlin Initiative Study (BIS), Chronic Kidney Disease Epidemiological Collaboration (CKD-EPI) and Full Age Spectrum (FAS) equations, and urinary albumin-to-creatinine ratio (ACR) was collected to categorize CKD according to Kidney Disease Improving Global Outcomes guidelines. Results Median age was 79.5 years (77.0–83.0), 804 (56.6%) were women. Using EWGSOP2 definition, 150 (10.6%) participants met diagnostic criteria for sarcopenia. Moreover, 85 (6%) participants had severe sarcopenia. Sarcopenia was more prevalent in participants with more advanced stages of CKD according to BIS eq. (9.6% in stages 1 and 2 and 13.9% in stages 3a, 3b and 4, p = 0.042), and also according to CKD-EPI (9.8% vs. 14.2%, p = 0.042) and FAS although not reaching statistical signification (9.8% vs. 12.7%, p = 0.119). Thus, differences in prevalence are observed among CKD categories as estimated by different equations. Prevalence of sarcopenia was also higher with increasing albuminuria categories: 9.3% in normoalbuminuric, 13.2% in microalbuminuric and 16.8% in macroalbuminuric participants, (p = 0.019). Conclusions Sarcopenia is common among community-dwelling older adults, especially among those with more advanced CKD categories, with prevalence estimates differing slightly depending on the equation used for the estimation of eGFR; as well as among those with higher albuminuria categories.
topic Older adults
Sarcopenia
Chronic kidney disease
Albuminuria
EWGSOP2
Estimated glomerular filtration rate
url http://link.springer.com/article/10.1186/s12877-020-01700-x
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spelling doaj-7c57405d70a940f5945142b0d27fb6352020-11-25T03:55:47ZengBMCBMC Geriatrics1471-23182020-10-0120S111210.1186/s12877-020-01700-xPrevalence of sarcopenia in community-dwelling older adults using the updated EWGSOP2 definition according to kidney function and albuminuriaRafael Moreno-Gonzalez0Xavier Corbella1Francesco Mattace-Raso2Lisanne Tap3Cornel Sieber4Ellen Freiberger5Tomasz Kostka6Agnieszka Guligowska7Itshak Melzer8Yehudit Melzer9Axel C. Carlsson10Johan Ärnlöv11Regina Roller-Wirnsberger12Gerhard Wirnsberger13Pedro Gil14Sara Lainez Martinez15Paolo Fabbietti16Andrea Corsonello17Fabrizia LattanzioFrancesc Formiga18on behalf of SCOPE investigatorsGeriatric Unit, Internal Medicine Department, Hospital Universitari de Bellvitge, Systemic Diseases and Ageing Group, Cardiovascular, Respiratory and Systemic Diseases and Cellular Aging Program, Institut d’Investigació Biomèdica de Bellvitge (IDIBELL), L’Hospitalet de LlobregatGeriatric Unit, Internal Medicine Department, Hospital Universitari de Bellvitge, Systemic Diseases and Ageing Group, Cardiovascular, Respiratory and Systemic Diseases and Cellular Aging Program, Institut d’Investigació Biomèdica de Bellvitge (IDIBELL), L’Hospitalet de LlobregatDepartment of Internal Medicine, Section of Geriatric Medicine, Erasmus MC, University Medical Center RotterdamDepartment of Internal Medicine, Section of Geriatric Medicine, Erasmus MC, University Medical Center RotterdamDepartment of Internal Medicine-Geriatrics, Institute for Biomedicine of Aging (IBA), Friedrich-Alexander-Universität Erlangen-NürnbergDepartment of Internal Medicine-Geriatrics, Institute for Biomedicine of Aging (IBA), Friedrich-Alexander-Universität Erlangen-NürnbergDepartment of Geriatrics, Healthy Ageing Research Centre, Medical University of LodzDepartment of Geriatrics, Healthy Ageing Research Centre, Medical University of LodzDepartment of Physical Therapy, Recanati School for Community Health Professions at the faculty of Health Sciences, Ben-Gurion University of the NegevDepartment of Physical Therapy, Recanati School for Community Health Professions at the faculty of Health Sciences, Ben-Gurion University of the NegevDepartment of Medical Sciences, Uppsala UniversityDepartment of Medical Sciences, Uppsala UniversityDepartment of Internal Medicine, Medical University of GrazDepartment of Internal Medicine, Medical University of GrazGeriatric Department, Hospital Clínico San CarlosGeriatric Department, Hospital Clínico San CarlosLaboratory of Geriatric Pharmacoepidemiology and Biostatistics, IRCCS INRCALaboratory of Geriatric Pharmacoepidemiology and Biostatistics, IRCCS INRCAGeriatric Unit, Internal Medicine Department, Hospital Universitari de Bellvitge, Systemic Diseases and Ageing Group, Cardiovascular, Respiratory and Systemic Diseases and Cellular Aging Program, Institut d’Investigació Biomèdica de Bellvitge (IDIBELL), L’Hospitalet de LlobregatAbstract Background Loss of muscle mass and function may be more pronounced in older adults with chronic kidney disease (CKD) and with albuminuria. Thus, we investigated the prevalence of sarcopenia among community-dwelling older adults according to kidney function and grade of albuminuria. We also explored differences in the prevalence of sarcopenia according to three different equations for the estimation of glomerular filtration rate (eGFR). Methods A cross-sectional analysis of 1420 community-dwelling older adults (≥75 years old) included in the SCOPE study, a multicenter prospective cohort study, was conducted. Comprehensive geriatric assessment including short physical performance battery (SPPB), handgrip strength test and bioelectrical impedance analysis (BIA) was performed. Sarcopenia was defined using the updated criteria of the European Working Group on Sarcopenia in Older People (EWGSOP2). eGFR was calculated using Berlin Initiative Study (BIS), Chronic Kidney Disease Epidemiological Collaboration (CKD-EPI) and Full Age Spectrum (FAS) equations, and urinary albumin-to-creatinine ratio (ACR) was collected to categorize CKD according to Kidney Disease Improving Global Outcomes guidelines. Results Median age was 79.5 years (77.0–83.0), 804 (56.6%) were women. Using EWGSOP2 definition, 150 (10.6%) participants met diagnostic criteria for sarcopenia. Moreover, 85 (6%) participants had severe sarcopenia. Sarcopenia was more prevalent in participants with more advanced stages of CKD according to BIS eq. (9.6% in stages 1 and 2 and 13.9% in stages 3a, 3b and 4, p = 0.042), and also according to CKD-EPI (9.8% vs. 14.2%, p = 0.042) and FAS although not reaching statistical signification (9.8% vs. 12.7%, p = 0.119). Thus, differences in prevalence are observed among CKD categories as estimated by different equations. Prevalence of sarcopenia was also higher with increasing albuminuria categories: 9.3% in normoalbuminuric, 13.2% in microalbuminuric and 16.8% in macroalbuminuric participants, (p = 0.019). Conclusions Sarcopenia is common among community-dwelling older adults, especially among those with more advanced CKD categories, with prevalence estimates differing slightly depending on the equation used for the estimation of eGFR; as well as among those with higher albuminuria categories.http://link.springer.com/article/10.1186/s12877-020-01700-xOlder adultsSarcopeniaChronic kidney diseaseAlbuminuriaEWGSOP2Estimated glomerular filtration rate