LncRNA KCNQ1OT1 affects cell proliferation, apoptosis and fibrosis through regulating miR-18b-5p/SORBS2 axis and NF-ĸB pathway in diabetic nephropathy

LncRNA KCNQ1OT1 affects cell proliferation, apoptosis and fibrosis through regulating miR-18b-5p/SORBS2 axis and NF-ĸB pathway in diabetic nephropathy

Abstract Background It has been reported that long non-coding RNAs (lncRNAs) play vital roles in diabetic nephropathy (DN). Our study aims to research the function of lncRNA KCNQ1OT1 in DN cells and the molecular mechanism. Methods Human glomerular mesangial cells (HGMCs) and human renal glomerular...

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Bibliographic Details
Main Authors: Ran Jie, Pengpeng Zhu, Jiao Zhong, Yan Zhang, Hongyan Wu
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Diabetology & Metabolic Syndrome
Subjects:
KCNQ1OT1
Diabetic nephropathy
miR-18b-5p
SORBS2
NF-ĸB pathway
Online Access:http://link.springer.com/article/10.1186/s13098-020-00585-5

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http://link.springer.com/article/10.1186/s13098-020-00585-5

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