Synthesis of Novel FTY720 Analogs with Anticancer Activity through PP2A Activation

Synthesis of Novel FTY720 Analogs with Anticancer Activity through PP2A Activation

FTY720 inhibits various cancers through PP2A activation. The structure of FTY720 is also used as a basic structure for the design of sphingosine kinase (SK) inhibitors. We have synthesized derivatives using an amide chain in FTY720 with a phenyl backbone, and then compounds were screened by an MTT c...

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Bibliographic Details
Main Authors: Jitendra Shrestha, Sung Hwan Ki, Sang Mi Shin, Seon Woong Kim, Joo-Youn Lee, Hee-Sook Jun, Taeho Lee, Sanghee Kim, Dong Jae Baek, Eun-Young Park
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Molecules
Subjects:
FTY720
protein phosphatase 2A
sphingosine kinase
colorectal cancer
derivative
Online Access:https://www.mdpi.com/1420-3049/23/11/2750

Internet

https://www.mdpi.com/1420-3049/23/11/2750

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