Strategies to improve the therapeutic effects of mesenchymal stromal cells in respiratory diseases
Abstract Due to their anti-inflammatory, antiapoptotic, antimicrobial, and antifibrotic properties, mesenchymal stromal cells (MSCs) have been considered a promising alternative for treatment of respiratory diseases. Nevertheless, even though MSC administration has been demonstrated to be safe in cl...
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doaj-7d0b1e3e817b457886e49d3e6cc36cd92020-11-25T01:32:47ZengBMCStem Cell Research & Therapy1757-65122018-02-01911910.1186/s13287-018-0802-8Strategies to improve the therapeutic effects of mesenchymal stromal cells in respiratory diseasesLuisa H. A. Silva0Mariana A. Antunes1Claudia C. Dos Santos2Daniel J. Weiss3Fernanda F. Cruz4Patricia R. M. Rocco5Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Centro de Ciências da SaúdeLaboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Centro de Ciências da SaúdeThe Keenan Research Centre for Biomedical Science of the Li Ka Shing Knowledge Institute of St. Michael’s HospitalDepartment of Medicine, Vermont Lung Center, College of Medicine, University of VermontLaboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Centro de Ciências da SaúdeLaboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Centro de Ciências da SaúdeAbstract Due to their anti-inflammatory, antiapoptotic, antimicrobial, and antifibrotic properties, mesenchymal stromal cells (MSCs) have been considered a promising alternative for treatment of respiratory diseases. Nevertheless, even though MSC administration has been demonstrated to be safe in clinical trials, to date, few studies have shown evidence of MSC efficacy in respiratory diseases. The present review describes strategies to enhance the beneficial effects of MSCs, including preconditioning (under hypoxia, oxidative stress, heat shock, serum deprivation, and exposure to inflammatory biological samples) and genetic manipulation. These strategies can variably promote increases in MSC survival rates, by inducing expression of cytoprotective genes, as well as increase MSC potency by improving secretion of reparative factors. Furthermore, these strategies have been demonstrated to enhance the beneficial effects of MSCs in preclinical lung disease models. However, there is still a long way to go before such strategies can be translated from bench to bedside.http://link.springer.com/article/10.1186/s13287-018-0802-8Mesenchymal stromal cellsHypoxiaSerum deprivationGenetic manipulation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Luisa H. A. Silva Mariana A. Antunes Claudia C. Dos Santos Daniel J. Weiss Fernanda F. Cruz Patricia R. M. Rocco |
spellingShingle |
Luisa H. A. Silva Mariana A. Antunes Claudia C. Dos Santos Daniel J. Weiss Fernanda F. Cruz Patricia R. M. Rocco Strategies to improve the therapeutic effects of mesenchymal stromal cells in respiratory diseases Stem Cell Research & Therapy Mesenchymal stromal cells Hypoxia Serum deprivation Genetic manipulation |
author_facet |
Luisa H. A. Silva Mariana A. Antunes Claudia C. Dos Santos Daniel J. Weiss Fernanda F. Cruz Patricia R. M. Rocco |
author_sort |
Luisa H. A. Silva |
title |
Strategies to improve the therapeutic effects of mesenchymal stromal cells in respiratory diseases |
title_short |
Strategies to improve the therapeutic effects of mesenchymal stromal cells in respiratory diseases |
title_full |
Strategies to improve the therapeutic effects of mesenchymal stromal cells in respiratory diseases |
title_fullStr |
Strategies to improve the therapeutic effects of mesenchymal stromal cells in respiratory diseases |
title_full_unstemmed |
Strategies to improve the therapeutic effects of mesenchymal stromal cells in respiratory diseases |
title_sort |
strategies to improve the therapeutic effects of mesenchymal stromal cells in respiratory diseases |
publisher |
BMC |
series |
Stem Cell Research & Therapy |
issn |
1757-6512 |
publishDate |
2018-02-01 |
description |
Abstract Due to their anti-inflammatory, antiapoptotic, antimicrobial, and antifibrotic properties, mesenchymal stromal cells (MSCs) have been considered a promising alternative for treatment of respiratory diseases. Nevertheless, even though MSC administration has been demonstrated to be safe in clinical trials, to date, few studies have shown evidence of MSC efficacy in respiratory diseases. The present review describes strategies to enhance the beneficial effects of MSCs, including preconditioning (under hypoxia, oxidative stress, heat shock, serum deprivation, and exposure to inflammatory biological samples) and genetic manipulation. These strategies can variably promote increases in MSC survival rates, by inducing expression of cytoprotective genes, as well as increase MSC potency by improving secretion of reparative factors. Furthermore, these strategies have been demonstrated to enhance the beneficial effects of MSCs in preclinical lung disease models. However, there is still a long way to go before such strategies can be translated from bench to bedside. |
topic |
Mesenchymal stromal cells Hypoxia Serum deprivation Genetic manipulation |
url |
http://link.springer.com/article/10.1186/s13287-018-0802-8 |
work_keys_str_mv |
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