Recent Advances in the Synthesis of High Boron-Loaded Nucleic Acids for BNCT

Boron clusters attract considerable attention as promising therapeutic tools for boron neutron capture therapy (BNCT). They combine high boron content with high chemical and biological stability, biorthogonality, and low toxicity. The development of oligonucleotide-based constructs and nucleic acid-...

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Main Authors:	Darya Sergeevna Novopashina, Mariya Alexandrovna Vorobyeva, Alya Venyaminova
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-03-01
Series:	Frontiers in Chemistry
Subjects:	boron cluster oligonucleotide conjugate conjugation method pre- and post-synthetic modification BNCT boron neutron capture therapy
Online Access:	https://www.frontiersin.org/articles/10.3389/fchem.2021.619052/full

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spelling	doaj-7d632a8582f84ffa97e6c36e1a86ffeb2021-03-15T05:03:51ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462021-03-01910.3389/fchem.2021.619052619052Recent Advances in the Synthesis of High Boron-Loaded Nucleic Acids for BNCTDarya Sergeevna NovopashinaMariya Alexandrovna VorobyevaAlya VenyaminovaBoron clusters attract considerable attention as promising therapeutic tools for boron neutron capture therapy (BNCT). They combine high boron content with high chemical and biological stability, biorthogonality, and low toxicity. The development of oligonucleotide-based constructs and nucleic acid-like molecules, such as oligomeric phosphate diesters, bearing one or multiple boron clusters permits to create potential high boron-loaded agents for BNCT with good bioavailability, specifically interacting with nucleic acids inside the cell. Here, we shortly review the strategies and solutions in the design of oligonucleotide conjugates with boron clusters in light of the requirements for effective BNCT and future prospects of their practical use.https://www.frontiersin.org/articles/10.3389/fchem.2021.619052/fullboron clusteroligonucleotide conjugateconjugation methodpre- and post-synthetic modificationBNCTboron neutron capture therapy
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Darya Sergeevna Novopashina Mariya Alexandrovna Vorobyeva Alya Venyaminova
spellingShingle	Darya Sergeevna Novopashina Mariya Alexandrovna Vorobyeva Alya Venyaminova Recent Advances in the Synthesis of High Boron-Loaded Nucleic Acids for BNCT Frontiers in Chemistry boron cluster oligonucleotide conjugate conjugation method pre- and post-synthetic modification BNCT boron neutron capture therapy
author_facet	Darya Sergeevna Novopashina Mariya Alexandrovna Vorobyeva Alya Venyaminova
author_sort	Darya Sergeevna Novopashina
title	Recent Advances in the Synthesis of High Boron-Loaded Nucleic Acids for BNCT
title_short	Recent Advances in the Synthesis of High Boron-Loaded Nucleic Acids for BNCT
title_full	Recent Advances in the Synthesis of High Boron-Loaded Nucleic Acids for BNCT
title_fullStr	Recent Advances in the Synthesis of High Boron-Loaded Nucleic Acids for BNCT
title_full_unstemmed	Recent Advances in the Synthesis of High Boron-Loaded Nucleic Acids for BNCT
title_sort	recent advances in the synthesis of high boron-loaded nucleic acids for bnct
publisher	Frontiers Media S.A.
series	Frontiers in Chemistry
issn	2296-2646
publishDate	2021-03-01
description	Boron clusters attract considerable attention as promising therapeutic tools for boron neutron capture therapy (BNCT). They combine high boron content with high chemical and biological stability, biorthogonality, and low toxicity. The development of oligonucleotide-based constructs and nucleic acid-like molecules, such as oligomeric phosphate diesters, bearing one or multiple boron clusters permits to create potential high boron-loaded agents for BNCT with good bioavailability, specifically interacting with nucleic acids inside the cell. Here, we shortly review the strategies and solutions in the design of oligonucleotide conjugates with boron clusters in light of the requirements for effective BNCT and future prospects of their practical use.
topic	boron cluster oligonucleotide conjugate conjugation method pre- and post-synthetic modification BNCT boron neutron capture therapy
url	https://www.frontiersin.org/articles/10.3389/fchem.2021.619052/full
work_keys_str_mv	AT daryasergeevnanovopashina recentadvancesinthesynthesisofhighboronloadednucleicacidsforbnct AT mariyaalexandrovnavorobyeva recentadvancesinthesynthesisofhighboronloadednucleicacidsforbnct AT alyavenyaminova recentadvancesinthesynthesisofhighboronloadednucleicacidsforbnct
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Recent Advances in the Synthesis of High Boron-Loaded Nucleic Acids for BNCT

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