Management of asthma in childhood: study protocol of a systematic evidence update by the Paediatric Asthma in Real Life (PeARL) Think Tank
Introduction Clinical recommendations for childhood asthma are often based on data extrapolated from studies conducted in adults, despite significant differences in mechanisms and response to treatments. The Paediatric Asthma in Real Life (PeARL) Think Tank aspires to develop recommendations based o...
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BMJ Publishing Group
2021-07-01
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Online Access: | https://bmjopen.bmj.com/content/11/7/e048338.full |
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language |
English |
format |
Article |
sources |
DOAJ |
author |
Jonathan Grigg Heather J Zar David Price Michael Miligkos Giuseppe De Carlo Peter N Le Souëf Tim Felton Graham Roberts Jose A Castro-Rodriguez Stephen Turner Alexander G Mathioudakis Gioulinta S Alimani Georgios A Mathioudakis Effie Papageorgiou Nikolaos G Papadopoulos Apostolos Beloukas Ioanna Tsiligianni Despo Ierodiakonou Tuomas Jartti A Deschildre Wojciech Feleszko Matteo Bonini Clare Murray Adnan Custovic Mário Morais-Almeida Wanda Phipatanakul Mika J Mäkelä Gunilla Hedlin Robert F Lemanske Paraskevi Xepapadaki James E Gern Cristina Boccabella Francine Monique Ducharme Omer Kalayci Antonio Nieto Garcia Ioana Octavia Agache Leonard Bacharier Timothy Craig Zuzana Diamant Elham M Hossny Alan Kaplan Paolo Matricardi Marina Mitrogiorgou Karthik Nagaraju Helena Pité Paulo M C Pitrez Petr Pohunek Susanne Vijverberg Tonya A Winders Gary WK Wong |
spellingShingle |
Jonathan Grigg Heather J Zar David Price Michael Miligkos Giuseppe De Carlo Peter N Le Souëf Tim Felton Graham Roberts Jose A Castro-Rodriguez Stephen Turner Alexander G Mathioudakis Gioulinta S Alimani Georgios A Mathioudakis Effie Papageorgiou Nikolaos G Papadopoulos Apostolos Beloukas Ioanna Tsiligianni Despo Ierodiakonou Tuomas Jartti A Deschildre Wojciech Feleszko Matteo Bonini Clare Murray Adnan Custovic Mário Morais-Almeida Wanda Phipatanakul Mika J Mäkelä Gunilla Hedlin Robert F Lemanske Paraskevi Xepapadaki James E Gern Cristina Boccabella Francine Monique Ducharme Omer Kalayci Antonio Nieto Garcia Ioana Octavia Agache Leonard Bacharier Timothy Craig Zuzana Diamant Elham M Hossny Alan Kaplan Paolo Matricardi Marina Mitrogiorgou Karthik Nagaraju Helena Pité Paulo M C Pitrez Petr Pohunek Susanne Vijverberg Tonya A Winders Gary WK Wong Management of asthma in childhood: study protocol of a systematic evidence update by the Paediatric Asthma in Real Life (PeARL) Think Tank BMJ Open |
author_facet |
Jonathan Grigg Heather J Zar David Price Michael Miligkos Giuseppe De Carlo Peter N Le Souëf Tim Felton Graham Roberts Jose A Castro-Rodriguez Stephen Turner Alexander G Mathioudakis Gioulinta S Alimani Georgios A Mathioudakis Effie Papageorgiou Nikolaos G Papadopoulos Apostolos Beloukas Ioanna Tsiligianni Despo Ierodiakonou Tuomas Jartti A Deschildre Wojciech Feleszko Matteo Bonini Clare Murray Adnan Custovic Mário Morais-Almeida Wanda Phipatanakul Mika J Mäkelä Gunilla Hedlin Robert F Lemanske Paraskevi Xepapadaki James E Gern Cristina Boccabella Francine Monique Ducharme Omer Kalayci Antonio Nieto Garcia Ioana Octavia Agache Leonard Bacharier Timothy Craig Zuzana Diamant Elham M Hossny Alan Kaplan Paolo Matricardi Marina Mitrogiorgou Karthik Nagaraju Helena Pité Paulo M C Pitrez Petr Pohunek Susanne Vijverberg Tonya A Winders Gary WK Wong |
author_sort |
Jonathan Grigg |
title |
Management of asthma in childhood: study protocol of a systematic evidence update by the Paediatric Asthma in Real Life (PeARL) Think Tank |
title_short |
Management of asthma in childhood: study protocol of a systematic evidence update by the Paediatric Asthma in Real Life (PeARL) Think Tank |
title_full |
Management of asthma in childhood: study protocol of a systematic evidence update by the Paediatric Asthma in Real Life (PeARL) Think Tank |
title_fullStr |
Management of asthma in childhood: study protocol of a systematic evidence update by the Paediatric Asthma in Real Life (PeARL) Think Tank |
title_full_unstemmed |
Management of asthma in childhood: study protocol of a systematic evidence update by the Paediatric Asthma in Real Life (PeARL) Think Tank |
title_sort |
management of asthma in childhood: study protocol of a systematic evidence update by the paediatric asthma in real life (pearl) think tank |
publisher |
BMJ Publishing Group |
series |
BMJ Open |
issn |
2044-6055 |
publishDate |
2021-07-01 |
description |
Introduction Clinical recommendations for childhood asthma are often based on data extrapolated from studies conducted in adults, despite significant differences in mechanisms and response to treatments. The Paediatric Asthma in Real Life (PeARL) Think Tank aspires to develop recommendations based on the best available evidence from studies in children. An overview of systematic reviews (SRs) on paediatric asthma maintenance management and an SR of treatments for acute asthma attacks in children, requiring an emergency presentation with/without hospital admission will be conducted.Methods and analysis Standard methodology recommended by Cochrane will be followed. Maintenance pharmacotherapy of childhood asthma will be evaluated in an overview of SRs published after 2005 and including clinical trials or real-life studies. For evaluating pharmacotherapy of acute asthma attacks leading to an emergency presentation with/without hospital admission, we opted to conduct de novo synthesis in the absence of adequate up-to-date published SRs. For the SR of acute asthma pharmacotherapy, we will consider eligible SRs, clinical trials or real-life studies without time restrictions. Our evidence updates will be based on broad searches of Pubmed/Medline and the Cochrane Library. We will use A MeaSurement Tool to Assess systematic Reviews, V.2, Cochrane risk of bias 2 and REal Life EVidence AssessmeNt Tool to evaluate the methodological quality of SRs, controlled clinical trials and real-life studies, respectively.Next, we will further assess interventions for acute severe asthma attacks with positive clinical results in meta-analyses. We will include both controlled clinical trials and observational studies and will assess their quality using the previously mentioned tools. We will employ random effect models for conducting meta-analyses, and Grading of Recommendations Assessment, Development and Evaluation methodology to assess certainty in the body of evidence.Ethics and dissemination Ethics approval is not required for SRs. Our findings will be published in peer reviewed journals and will inform clinical recommendations being developed by the PeARL Think Tank.PROSPERO registration numbers CRD42020132990, CRD42020171624. |
url |
https://bmjopen.bmj.com/content/11/7/e048338.full |
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doaj-7da0701f3db645d682a85f343fc77ba92021-10-06T13:00:04ZengBMJ Publishing GroupBMJ Open2044-60552021-07-0111710.1136/bmjopen-2020-048338Management of asthma in childhood: study protocol of a systematic evidence update by the Paediatric Asthma in Real Life (PeARL) Think TankJonathan Grigg0Heather J Zar1David Price2Michael Miligkos3Giuseppe De Carlo4Peter N Le Souëf5Tim Felton6Graham Roberts7Jose A Castro-Rodriguez8Stephen Turner9Alexander G Mathioudakis10Gioulinta S Alimani11Georgios A Mathioudakis12Effie Papageorgiou13Nikolaos G Papadopoulos14Apostolos Beloukas15Ioanna Tsiligianni16Despo Ierodiakonou17Tuomas Jartti18A Deschildre19Wojciech Feleszko20Matteo Bonini21Clare Murray22Adnan Custovic23Mário Morais-Almeida24Wanda Phipatanakul25Mika J Mäkelä26Gunilla Hedlin27Robert F Lemanske28Paraskevi Xepapadaki29James E Gern30Cristina Boccabella31Francine Monique Ducharme32Omer Kalayci33Antonio Nieto Garcia34Ioana Octavia Agache35Leonard Bacharier36Timothy Craig37Zuzana Diamant38Elham M Hossny39Alan Kaplan40Paolo Matricardi41Marina Mitrogiorgou42Karthik Nagaraju43Helena Pité44Paulo M C Pitrez45Petr Pohunek46Susanne Vijverberg47Tonya A Winders48Gary WK Wong49Centre for Genomics and Child Health, Blizard Institute, Queen Mary University of London, London, UKDepartment of Paediatrics and Child Health, Red Cross War Memorial Children’s Hospital, University of Cape Town, Rondebosch, Western Cape, South AfricaCentre of Academic Primary Care, University of Aberdeen, Aberdeen, UKFirst Department of Pediatrics, Aghia Sofia Children`s Hospital, University of Athens, Athens, Attica, GreeceAllergy and Airway Diseases Patient`s Associations, European Federation of Pharmaceutical Industries and Associations, Brussels, BelgiumSchool of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia, AustraliaDivision of Infection, Immunity and Respiratory Medicine, The University of Manchester, Manchester, UKThe David Hide Asthma and Allergy Research Centre, St Mary`s Hospital, Newport Isle of Wight, UKDepartment of Pediatrics, Pontifical Universidad Catolica de Chile, Santiago, ChileDepartment of Child Health, University of Aberdeen, Aberdeen, Aberdeen, UKDivision of Infection, Immunity and Respiratory Medicine, The University of Manchester, Manchester, UKAthens Breath Centre, Athens, GreeceAthens Breath Centre, Athens, GreeceDepartment of Biomedical Sciences, University of West Attica, Egaleo, Attica, GreeceDivision of Infection, Immunity and Respiratory Medicine, The University of Manchester, Manchester, UKDepartment of Biomedical Sciences, University of West Attica, Egaleo, Attica, GreeceDepartment of Social Medicine, Faculty of Medicine, University of Crete, Rethimno, GreeceDepartment of Social Medicine, Faculty of Medicine, University of Crete, Rethimno, GreeceDepartment of Paediatrics, University of Turku, Turku, FinlandUnité de Pneumologie et Allergologie Pédiatriques, Hôpital Jeanne de Flandre, CHU Lille, Lille, Hauts-de-France, FranceDepartment of Pediatric Pulmonology and Allergy, Medical University of Warsaw, Warszawa, PolandDepartment of Cardiovascular and Thoracic Sciences, Catholic University of the Sacred Heart, Milano, Lombardia, ItalyDivision of Infection, Immunity and Respiratory Medicine, The University of Manchester, Manchester, UKDepartment of Paediatrics, Imperial College London, London, UKAllergy Center, Hospital CUF Descobertas, Lisboa, PortugalPediatric Allergy and Immunology, Children`s Hospital Boston, Boston, Massachusetts, USADepartment of Allergy, University of Helsinki, Helsinki, Uusimaa, FinlandDepartment of Women`s and Children`s Health, Karolinska Institute, Stockholm, Stockholm, SwedenDepartment of Pediatrics and Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USAAllergy Department, 2nd Paediatric Clinic, National and Kapodistrian University of Athens, Athens, Attica, GreeceDepartment of Pediatrics and Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USADepartment of Cardiovascular and Thoracic Sciences, Catholic University of the Sacred Heart, Milano, Lombardia, ItalyPediatrics, University of Montreal, Montreal, Quebec, CanadaPediatric Allergy and Asthma Unit, Hacettepe Universitesi, Ankara, TurkeyPulmonology and Allergy Unity, La Fe University and Polytechnic Hospital, Valencia, Comunidad Valenciana, SpainAllergy and Clinical Immunology, Transylvania University, Brasov, RomaniaDepartment of Allergy, Immunology, and Pulmonary Medicine, University of Washington, Seattle, Washington, USAAllergy, Asthma and Immunology, Penn State University, Hershey, Pennsylvania, USADepartment of Respiratory Medicine and Allergology, Institute for Clinical Science, Skane University Hospital Lund Hematological Clinic, Lund, Skåne, SwedenPediatric Allergy and Immunology Unit, Ain Shams University, Cairo, EgyptFamily Physician, Airways Group of Canada, University of Toronto, Toronto, Ontario, CanadaDepartment of Pediatric Pulmonology, Immunology and Intensive Care Medicine, Charité - University Medicine, Berlin, GermanyThird Department of Paediatrics, National and Kapodistrian University of Athens School of Health Sciences, Athens, GreeceAllergy & Asthma, VN, Chennai, IndiaAllergy Center, Hospital CUF Descobertas, Lisboa, PortugalLaboratory of Respiratory Physiology, Infant Center, School of Medicine, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, BrazilPaediatric Department, Motol University Hospital, Praha, Czech RepublicDepartment of Respiratory Medicine and Department of Pediatric Pulmonology, University of Amsterdam, Amsterdam, NetherlandsAllergy & Asthma, Global Patient Platform, Virginia, Virginia, USADepartment of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Sha Tin, Hong KongIntroduction Clinical recommendations for childhood asthma are often based on data extrapolated from studies conducted in adults, despite significant differences in mechanisms and response to treatments. The Paediatric Asthma in Real Life (PeARL) Think Tank aspires to develop recommendations based on the best available evidence from studies in children. An overview of systematic reviews (SRs) on paediatric asthma maintenance management and an SR of treatments for acute asthma attacks in children, requiring an emergency presentation with/without hospital admission will be conducted.Methods and analysis Standard methodology recommended by Cochrane will be followed. Maintenance pharmacotherapy of childhood asthma will be evaluated in an overview of SRs published after 2005 and including clinical trials or real-life studies. For evaluating pharmacotherapy of acute asthma attacks leading to an emergency presentation with/without hospital admission, we opted to conduct de novo synthesis in the absence of adequate up-to-date published SRs. For the SR of acute asthma pharmacotherapy, we will consider eligible SRs, clinical trials or real-life studies without time restrictions. Our evidence updates will be based on broad searches of Pubmed/Medline and the Cochrane Library. We will use A MeaSurement Tool to Assess systematic Reviews, V.2, Cochrane risk of bias 2 and REal Life EVidence AssessmeNt Tool to evaluate the methodological quality of SRs, controlled clinical trials and real-life studies, respectively.Next, we will further assess interventions for acute severe asthma attacks with positive clinical results in meta-analyses. We will include both controlled clinical trials and observational studies and will assess their quality using the previously mentioned tools. We will employ random effect models for conducting meta-analyses, and Grading of Recommendations Assessment, Development and Evaluation methodology to assess certainty in the body of evidence.Ethics and dissemination Ethics approval is not required for SRs. Our findings will be published in peer reviewed journals and will inform clinical recommendations being developed by the PeARL Think Tank.PROSPERO registration numbers CRD42020132990, CRD42020171624.https://bmjopen.bmj.com/content/11/7/e048338.full |