The Initiation, but Not the Persistence, of Experimental Spondyloarthritis Is Dependent on Interleukin-23 Signaling

The Initiation, but Not the Persistence, of Experimental Spondyloarthritis Is Dependent on Interleukin-23 Signaling

IL-17A is a central driver of spondyloarthritis (SpA), its production was originally proposed to be IL-23 dependent. Emerging preclinical and clinical evidence suggests, however, that IL-17A and IL-23 have a partially overlapping but distinct biology. We aimed to assess the extent to which IL-17A-dr...

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Bibliographic Details
Main Authors: Melissa N. van Tok, Songqing Na, Christopher R. Lao, Marina Alvi, Desirée Pots, Marleen G. H. van de Sande, Joel D. Taurog, Jonathon D. Sedgwick, Dominique L. Baeten, Leonie M. van Duivenvoorde
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
spondyloarthritis
animal models
HLA-B27 tg rats
IL-23R
IL-23 signaling
IL-17A
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01550/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01550/full

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