Inhibitory Effect of Azimilide on Na+/Ca2+ Exchange Current in Guinea-Pig Cardiac Myocytes

We examined the effect of azimilide, a class III antiarrhythmic drug, on Na+/Ca2+ exchange current (INCX) in guinea-pig cardiac single ventricular cells. External application of azimilide suppressed bi-directional INCX in a concentration-dependent manner. IC50 values for outward and inward INCX were...

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Bibliographic Details
Main Authors: Yasuhide Watanabe, Junko Kimura
Format: Article
Published: Elsevier 2010-01-01
Series:Journal of Pharmacological Sciences
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