High Mannose N-Glycans Promote Migration of Bone-Marrow-Derived Mesenchymal Stromal Cells

High Mannose N-Glycans Promote Migration of Bone-Marrow-Derived Mesenchymal Stromal Cells

For hundreds of indications, mesenchymal stromal cells (MSCs) have not achieved the expected therapeutic efficacy due to an inability of the cells to reach target tissues. We show that inducing high mannose N-glycans either chemically, using the mannosidase I inhibitor Kifunensine, or genetically, u...

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Bibliographic Details
Main Authors: Vivian Alonso-Garcia, Cutter Chaboya, Qiongyu Li, Bryan Le, Timothy J. Congleton, Jose Florez, Victoria Tran, Gang-Yu Liu, Wei Yao, Carlito B. Lebrilla, Fernando A. Fierro
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
mesenchymal stromal cells
amino-linked glycans
MAN1A1
Kifunensine
migration
bone fracture
Online Access:https://www.mdpi.com/1422-0067/21/19/7194

Internet

https://www.mdpi.com/1422-0067/21/19/7194

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