Computational and experimental characterization of 3D-printed PCL structures toward the design of soft biological tissue scaffolds
Degradable porous polymeric structures are attractive candidates for biological tissue scaffolds, and adequate mechanical, transport, chemical and biological properties determine their functionality. Aside from the properties of polymer-based materials, the scaffold's meso-structure controls it...
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doaj-7eef2559a9e0480198972a7b776d4d392020-11-25T02:36:23ZengElsevierMaterials & Design0264-12752020-03-01188Computational and experimental characterization of 3D-printed PCL structures toward the design of soft biological tissue scaffoldsHailong Liu0Astrid Ahlinder1Mohammed A. Yassin2Anna Finne-Wistrand3T. Christian Gasser4Department of Fibre and Polymer Technology, KTH Royal Institute of Technology, Stockholm, Sweden; Department of Solid Mechanics, KTH Royal Institute of Technology, Stockholm, Sweden; Corresponding author at: Department of Fibre and Polymer Technology, KTH Royal Institute of Technology, Stockholm, Sweden.Department of Fibre and Polymer Technology, KTH Royal Institute of Technology, Stockholm, SwedenDepartment of Clinical Dentistry, University of Bergen, Bergen, NorwayDepartment of Fibre and Polymer Technology, KTH Royal Institute of Technology, Stockholm, SwedenDepartment of Solid Mechanics, KTH Royal Institute of Technology, Stockholm, SwedenDegradable porous polymeric structures are attractive candidates for biological tissue scaffolds, and adequate mechanical, transport, chemical and biological properties determine their functionality. Aside from the properties of polymer-based materials, the scaffold's meso-structure controls its elasticity at the organ length-scale. This study investigated the effect of the meso-structure on scaffolds' mechanical and transport properties using finite element analysis (FEA) and computational fluid dynamics (CFD). A number of poly (ε-caprolactone) (PCL) - based scaffolds were 3D printed, analyzed by microcomputed tomography (micro-CT) and mechanically tested. We found that the gradient (G) and gradient and staggered (GS) meso-structure designs led to a higher scaffold permeability, a more homogeneous flow inside the scaffold, and a lower wall shear stress (WSS) in comparison with the basic (B) meso-structure design. The GS design resulted in scaffold stiffness as low as 1.07/0.97 MPa under compression/tension, figures that are comparative with several soft tissues. Image processing of micro-CT data demonstrated that the imposed meso-structures could have been adequately realized through 3D printing, and experimental testing validated FEA analysis. Our results suggest that the properties of 3D-printed PCL-based scaffolds can be tuned via meso-structures toward soft tissue engineering applications. The biological function of designed scaffolds should be further explored in-situ studies. Keywords: Scaffold, 3D printing, Meso-structure, Finite element analysis, Computational fluid dynamics, Soft tissue engineeringhttp://www.sciencedirect.com/science/article/pii/S0264127520300216 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hailong Liu Astrid Ahlinder Mohammed A. Yassin Anna Finne-Wistrand T. Christian Gasser |
spellingShingle |
Hailong Liu Astrid Ahlinder Mohammed A. Yassin Anna Finne-Wistrand T. Christian Gasser Computational and experimental characterization of 3D-printed PCL structures toward the design of soft biological tissue scaffolds Materials & Design |
author_facet |
Hailong Liu Astrid Ahlinder Mohammed A. Yassin Anna Finne-Wistrand T. Christian Gasser |
author_sort |
Hailong Liu |
title |
Computational and experimental characterization of 3D-printed PCL structures toward the design of soft biological tissue scaffolds |
title_short |
Computational and experimental characterization of 3D-printed PCL structures toward the design of soft biological tissue scaffolds |
title_full |
Computational and experimental characterization of 3D-printed PCL structures toward the design of soft biological tissue scaffolds |
title_fullStr |
Computational and experimental characterization of 3D-printed PCL structures toward the design of soft biological tissue scaffolds |
title_full_unstemmed |
Computational and experimental characterization of 3D-printed PCL structures toward the design of soft biological tissue scaffolds |
title_sort |
computational and experimental characterization of 3d-printed pcl structures toward the design of soft biological tissue scaffolds |
publisher |
Elsevier |
series |
Materials & Design |
issn |
0264-1275 |
publishDate |
2020-03-01 |
description |
Degradable porous polymeric structures are attractive candidates for biological tissue scaffolds, and adequate mechanical, transport, chemical and biological properties determine their functionality. Aside from the properties of polymer-based materials, the scaffold's meso-structure controls its elasticity at the organ length-scale. This study investigated the effect of the meso-structure on scaffolds' mechanical and transport properties using finite element analysis (FEA) and computational fluid dynamics (CFD). A number of poly (ε-caprolactone) (PCL) - based scaffolds were 3D printed, analyzed by microcomputed tomography (micro-CT) and mechanically tested. We found that the gradient (G) and gradient and staggered (GS) meso-structure designs led to a higher scaffold permeability, a more homogeneous flow inside the scaffold, and a lower wall shear stress (WSS) in comparison with the basic (B) meso-structure design. The GS design resulted in scaffold stiffness as low as 1.07/0.97 MPa under compression/tension, figures that are comparative with several soft tissues. Image processing of micro-CT data demonstrated that the imposed meso-structures could have been adequately realized through 3D printing, and experimental testing validated FEA analysis. Our results suggest that the properties of 3D-printed PCL-based scaffolds can be tuned via meso-structures toward soft tissue engineering applications. The biological function of designed scaffolds should be further explored in-situ studies. Keywords: Scaffold, 3D printing, Meso-structure, Finite element analysis, Computational fluid dynamics, Soft tissue engineering |
url |
http://www.sciencedirect.com/science/article/pii/S0264127520300216 |
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