Mesenchymal stem cells recruited by castration-induced inflammation activation accelerate prostate cancer hormone resistance via chemokine ligand 5 secretion

Mesenchymal stem cells recruited by castration-induced inflammation activation accelerate prostate cancer hormone resistance via chemokine ligand 5 secretion

Abstract Background Androgen deprivation (AD) as the first-line treatment for advanced prostate cancer (PCa) is insufficient for a long-term effect. Castration resistance remains the greatest obstacle in PCa clinical therapy. Mesenchymal stem cells (MSCs) can migrate into PCa tissues contributing to...

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Bibliographic Details
Main Authors: Yang Yu, Qingyun Zhang, Chengzhong Ma, Xue Yang, Rui Lin, Hongxiang Zhang, Yan Liu, Zhipeng Han, Jiwen Cheng
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem cell
Cancer stem cell
Tumor microenvironment
Oxidative stress
Castration resistance
Online Access:http://link.springer.com/article/10.1186/s13287-018-0989-8

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http://link.springer.com/article/10.1186/s13287-018-0989-8

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