Raf1 Is a DCAF for the Rik1 DDB1-like protein and has separable roles in siRNA generation and chromatin modification.

Raf1 Is a DCAF for the Rik1 DDB1-like protein and has separable roles in siRNA generation and chromatin modification.

Non-coding transcription can trigger histone post-translational modifications forming specialized chromatin. In fission yeast, heterochromatin formation requires RNAi and the histone H3K9 methyltransferase complex CLRC, composed of Clr4, Raf1, Raf2, Cul4, and Rik1. CLRC mediates H3K9 methylation and...

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Main Authors: Alessia Buscaino, Sharon A White, Douglas R Houston, Erwan Lejeune, Femke Simmer, Flavia de Lima Alves, Piyush T Diyora, Takeshi Urano, Elizabeth H Bayne, Juri Rappsilber, Robin C Allshire
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-02-01
Series:PLoS Genetics
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22319459/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22319459/pdf/?tool=EBI

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