Therapeutic Potential of GABAergic Signaling in Myelin Plasticity and Repair
Oligodendrocytes (OLs) produce myelin to insulate axons. This accelerates action potential propagation, allowing nerve impulse information to synchronize within complex neuronal ensembles and promoting brain connectivity. Brain plasticity includes myelination, a process that starts early after birth...
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2021-04-01
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Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.662191/full |
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doaj-7fbd212282a74e578b54a16390fe713a2021-04-06T05:32:04ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-04-01910.3389/fcell.2021.662191662191Therapeutic Potential of GABAergic Signaling in Myelin Plasticity and RepairDaniel Reyes-HaroAbraham Cisneros-MejoradoRogelio O. ArellanoOligodendrocytes (OLs) produce myelin to insulate axons. This accelerates action potential propagation, allowing nerve impulse information to synchronize within complex neuronal ensembles and promoting brain connectivity. Brain plasticity includes myelination, a process that starts early after birth and continues throughout life. Myelin repair, followed by injury or disease, requires new OLs differentiated from a population derived from oligodendrocyte precursor cells (OPCs) that continue to proliferate, migrate and differentiate to preserve and remodel myelin in the adult central nervous system. OPCs represent the largest proliferative neural cell population outside the adult neurogenic niches in the brain. OPCs receive synaptic inputs from glutamatergic and GABAergic neurons throughout neurodevelopment, a unique feature among glial cells. Neuron-glia communication through GABA signaling in OPCs has been shown to play a role in myelin plasticity and repair. In this review we will focus on the molecular and functional properties of GABAA receptors (GABAARs) expressed by OPCs and their potential role in remyelination.https://www.frontiersin.org/articles/10.3389/fcell.2021.662191/fullGABAA receptorsoligodendrocyte precursor cellsNG2 gliamyelinationremyelinationβ-carbolines |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Daniel Reyes-Haro Abraham Cisneros-Mejorado Rogelio O. Arellano |
spellingShingle |
Daniel Reyes-Haro Abraham Cisneros-Mejorado Rogelio O. Arellano Therapeutic Potential of GABAergic Signaling in Myelin Plasticity and Repair Frontiers in Cell and Developmental Biology GABAA receptors oligodendrocyte precursor cells NG2 glia myelination remyelination β-carbolines |
author_facet |
Daniel Reyes-Haro Abraham Cisneros-Mejorado Rogelio O. Arellano |
author_sort |
Daniel Reyes-Haro |
title |
Therapeutic Potential of GABAergic Signaling in Myelin Plasticity and Repair |
title_short |
Therapeutic Potential of GABAergic Signaling in Myelin Plasticity and Repair |
title_full |
Therapeutic Potential of GABAergic Signaling in Myelin Plasticity and Repair |
title_fullStr |
Therapeutic Potential of GABAergic Signaling in Myelin Plasticity and Repair |
title_full_unstemmed |
Therapeutic Potential of GABAergic Signaling in Myelin Plasticity and Repair |
title_sort |
therapeutic potential of gabaergic signaling in myelin plasticity and repair |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cell and Developmental Biology |
issn |
2296-634X |
publishDate |
2021-04-01 |
description |
Oligodendrocytes (OLs) produce myelin to insulate axons. This accelerates action potential propagation, allowing nerve impulse information to synchronize within complex neuronal ensembles and promoting brain connectivity. Brain plasticity includes myelination, a process that starts early after birth and continues throughout life. Myelin repair, followed by injury or disease, requires new OLs differentiated from a population derived from oligodendrocyte precursor cells (OPCs) that continue to proliferate, migrate and differentiate to preserve and remodel myelin in the adult central nervous system. OPCs represent the largest proliferative neural cell population outside the adult neurogenic niches in the brain. OPCs receive synaptic inputs from glutamatergic and GABAergic neurons throughout neurodevelopment, a unique feature among glial cells. Neuron-glia communication through GABA signaling in OPCs has been shown to play a role in myelin plasticity and repair. In this review we will focus on the molecular and functional properties of GABAA receptors (GABAARs) expressed by OPCs and their potential role in remyelination. |
topic |
GABAA receptors oligodendrocyte precursor cells NG2 glia myelination remyelination β-carbolines |
url |
https://www.frontiersin.org/articles/10.3389/fcell.2021.662191/full |
work_keys_str_mv |
AT danielreyesharo therapeuticpotentialofgabaergicsignalinginmyelinplasticityandrepair AT abrahamcisnerosmejorado therapeuticpotentialofgabaergicsignalinginmyelinplasticityandrepair AT rogeliooarellano therapeuticpotentialofgabaergicsignalinginmyelinplasticityandrepair |
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