Membrane-Bound CD40L Promotes Senescence and Initiates Senescence-Associated Secretory Phenotype via NF-κB Activation in Lung Adenocarcinoma

Membrane-Bound CD40L Promotes Senescence and Initiates Senescence-Associated Secretory Phenotype via NF-κB Activation in Lung Adenocarcinoma

Background/Aims: Cellular senescence acts as a barrier against tumorigenesis. The CD40L transgene, expressed in some tumor cells, not only becomes visible to antigen-presenting cells but also actively catalyzes its own termination. Here, we evaluated the effect of a membrane-bound mutant form of hum...

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Bibliographic Details
Main Authors: Wei Xu, Yue Li, Wei-Wei Yuan, Yuan Yin, Wei-Wei Song, Yu Wang, Qi-Qing Huang, Wei-Hong Zhao, Jian-Qing Wu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-08-01
Series:Cellular Physiology and Biochemistry
Subjects:
Cd40l mutant
Lung adenocarcinoma
Senescence
SASP
NF-κB
Online Access:https://www.karger.com/Article/FullText/492352

Internet

https://www.karger.com/Article/FullText/492352

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