The effect of curculigoside on mouse model of perimenopausal depression
Objective: To investigate the effect of curculigoside on mice with simulated perimenopausal depression. Method: Gavage with high, medium, small dose of curculigoside once daily for 30 d consecutive days. Record the related behavior index. The wet weights and viscera indexes of the mouse uterus, thym...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2017-12-01
|
Series: | Saudi Journal of Biological Sciences |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1319562X17303078 |
id |
doaj-803f5d88a1974d3ab3be133bfee3f04d |
---|---|
record_format |
Article |
spelling |
doaj-803f5d88a1974d3ab3be133bfee3f04d2020-11-24T23:14:23ZengElsevierSaudi Journal of Biological Sciences1319-562X2017-12-012481894190210.1016/j.sjbs.2017.11.033The effect of curculigoside on mouse model of perimenopausal depressionMingsan MiaoShuo TianLin GuoMing BaiXiaoyan FangShaoyan LiuObjective: To investigate the effect of curculigoside on mice with simulated perimenopausal depression. Method: Gavage with high, medium, small dose of curculigoside once daily for 30 d consecutive days. Record the related behavior index. The wet weights and viscera indexes of the mouse uterus, thymus, and spleen were measured. Half of the brain was homogenized and tested for 5-HT and DA concentrations. The levels of serum E2, T, FSH, and LH were measured as well. Finally, histological changes in the uterus, thymus, spleen, and hypothalamus were observed under a light microscope. Result: curculigoside can enhance the activity and latency time of the mice, increase mouse memory, and decrease electric shocks and immobility times in the TST and FST experiments. Mice treated with curculigoside showed significantly enhancement in viscera indexes of the thymus, spleen, and uterus; significantly elevated levels of serum E2 and T; significantly increased brain 5-HT and DA concentrations; significantly decreased levels of serum FSH and LH; and improvements in the histopathological lesions of the uterus, hypothalamus, thymus, and spleen. The high dose of curculigoside produced the best results. Conclusion: All doses of curculigoside are associated with reversing hormone (E2, T, FSH, and LH) disorders in perimenopausal syndrome and adjusting imbalanced 5-HT and DA levels, representing a therapeutic effect in perimenopausal depression.http://www.sciencedirect.com/science/article/pii/S1319562X17303078CurculigosidePerimenopausal depressionAnimal model |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mingsan Miao Shuo Tian Lin Guo Ming Bai Xiaoyan Fang Shaoyan Liu |
spellingShingle |
Mingsan Miao Shuo Tian Lin Guo Ming Bai Xiaoyan Fang Shaoyan Liu The effect of curculigoside on mouse model of perimenopausal depression Saudi Journal of Biological Sciences Curculigoside Perimenopausal depression Animal model |
author_facet |
Mingsan Miao Shuo Tian Lin Guo Ming Bai Xiaoyan Fang Shaoyan Liu |
author_sort |
Mingsan Miao |
title |
The effect of curculigoside on mouse model of perimenopausal depression |
title_short |
The effect of curculigoside on mouse model of perimenopausal depression |
title_full |
The effect of curculigoside on mouse model of perimenopausal depression |
title_fullStr |
The effect of curculigoside on mouse model of perimenopausal depression |
title_full_unstemmed |
The effect of curculigoside on mouse model of perimenopausal depression |
title_sort |
effect of curculigoside on mouse model of perimenopausal depression |
publisher |
Elsevier |
series |
Saudi Journal of Biological Sciences |
issn |
1319-562X |
publishDate |
2017-12-01 |
description |
Objective: To investigate the effect of curculigoside on mice with simulated perimenopausal depression.
Method: Gavage with high, medium, small dose of curculigoside once daily for 30 d consecutive days. Record the related behavior index. The wet weights and viscera indexes of the mouse uterus, thymus, and spleen were measured. Half of the brain was homogenized and tested for 5-HT and DA concentrations. The levels of serum E2, T, FSH, and LH were measured as well. Finally, histological changes in the uterus, thymus, spleen, and hypothalamus were observed under a light microscope.
Result: curculigoside can enhance the activity and latency time of the mice, increase mouse memory, and decrease electric shocks and immobility times in the TST and FST experiments. Mice treated with curculigoside showed significantly enhancement in viscera indexes of the thymus, spleen, and uterus; significantly elevated levels of serum E2 and T; significantly increased brain 5-HT and DA concentrations; significantly decreased levels of serum FSH and LH; and improvements in the histopathological lesions of the uterus, hypothalamus, thymus, and spleen. The high dose of curculigoside produced the best results.
Conclusion: All doses of curculigoside are associated with reversing hormone (E2, T, FSH, and LH) disorders in perimenopausal syndrome and adjusting imbalanced 5-HT and DA levels, representing a therapeutic effect in perimenopausal depression. |
topic |
Curculigoside Perimenopausal depression Animal model |
url |
http://www.sciencedirect.com/science/article/pii/S1319562X17303078 |
work_keys_str_mv |
AT mingsanmiao theeffectofcurculigosideonmousemodelofperimenopausaldepression AT shuotian theeffectofcurculigosideonmousemodelofperimenopausaldepression AT linguo theeffectofcurculigosideonmousemodelofperimenopausaldepression AT mingbai theeffectofcurculigosideonmousemodelofperimenopausaldepression AT xiaoyanfang theeffectofcurculigosideonmousemodelofperimenopausaldepression AT shaoyanliu theeffectofcurculigosideonmousemodelofperimenopausaldepression AT mingsanmiao effectofcurculigosideonmousemodelofperimenopausaldepression AT shuotian effectofcurculigosideonmousemodelofperimenopausaldepression AT linguo effectofcurculigosideonmousemodelofperimenopausaldepression AT mingbai effectofcurculigosideonmousemodelofperimenopausaldepression AT xiaoyanfang effectofcurculigosideonmousemodelofperimenopausaldepression AT shaoyanliu effectofcurculigosideonmousemodelofperimenopausaldepression |
_version_ |
1725594653115285504 |