Human Natural Killer Cells Prevent Infectious Mononucleosis Features by Targeting Lytic Epstein-Barr Virus Infection
Primary infection with the human oncogenic Epstein-Barr virus (EBV) can result in infectious mononucleosis (IM), a self-limiting disease caused by massive lymphocyte expansion that predisposes for the development of distinct EBV-associated lymphomas. Why some individuals experience this symptomatic...
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2013-12-01
|
| Series: | Cell Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124713007250 |
| id |
doaj-8068eed82c1d4db5b6f3b53c1e9437e1 |
|---|---|
| record_format |
Article |
| spelling |
doaj-8068eed82c1d4db5b6f3b53c1e9437e12020-11-25T01:09:27ZengElsevierCell Reports2211-12472013-12-01561489149810.1016/j.celrep.2013.11.041Human Natural Killer Cells Prevent Infectious Mononucleosis Features by Targeting Lytic Epstein-Barr Virus InfectionObinna Chijioke0Anne Müller1Regina Feederle2Mario Henrique M. Barros3Carsten Krieg4Vanessa Emmel5Emanuela Marcenaro6Carol S. Leung7Olga Antsiferova8Vanessa Landtwing9Walter Bossart10Alessandro Moretta11Rocio Hassan12Onur Boyman13Gerald Niedobitek14Henri-Jacques Delecluse15Riccarda Capaul16Christian Münz17Department of Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, 8057 Zürich, SwitzerlandDepartment of Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, 8057 Zürich, SwitzerlandDKFZ unit F100/INSERM unit U1074, 69120 Heidelberg, GermanyInstitute for Pathology, Unfallkrankenhaus Berlin, 12683 Berlin, GermanyLaboratory of Applied Immunobiology, University of Zürich, 8006 Zürich, SwitzerlandBone Marrow Transplantation Center, Instituto Nacional de Cancer (INCA), 20231-130 Rio de Janeiro, BrazilDipartimento di Medicina Sperimentale, Università degli Studi di Genova, 16147 Genova, ItalyDepartment of Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, 8057 Zürich, SwitzerlandDepartment of Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, 8057 Zürich, SwitzerlandDepartment of Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, 8057 Zürich, SwitzerlandInstitute of Medical Virology, University of Zürich, 8006 Zürich, SwitzerlandDipartimento di Medicina Sperimentale, Università degli Studi di Genova, 16147 Genova, ItalyBone Marrow Transplantation Center, Instituto Nacional de Cancer (INCA), 20231-130 Rio de Janeiro, BrazilLaboratory of Applied Immunobiology, University of Zürich, 8006 Zürich, SwitzerlandInstitute for Pathology, Unfallkrankenhaus Berlin, 12683 Berlin, GermanyDKFZ unit F100/INSERM unit U1074, 69120 Heidelberg, GermanyInstitute of Medical Virology, University of Zürich, 8006 Zürich, SwitzerlandDepartment of Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, 8057 Zürich, Switzerland Primary infection with the human oncogenic Epstein-Barr virus (EBV) can result in infectious mononucleosis (IM), a self-limiting disease caused by massive lymphocyte expansion that predisposes for the development of distinct EBV-associated lymphomas. Why some individuals experience this symptomatic primary EBV infection, whereas the majority acquires the virus asymptomatically, remains unclear. Using a mouse model with reconstituted human immune system components, we show that depletion of human natural killer (NK) cells enhances IM symptoms and promotes EBV-associated tumorigenesis mainly because of a loss of immune control over lytic EBV infection. These data suggest that failure of innate immune control by human NK cells augments symptomatic lytic EBV infection, which drives lymphocyte expansion and predisposes for EBV-associated malignancies. http://www.sciencedirect.com/science/article/pii/S2211124713007250 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Obinna Chijioke Anne Müller Regina Feederle Mario Henrique M. Barros Carsten Krieg Vanessa Emmel Emanuela Marcenaro Carol S. Leung Olga Antsiferova Vanessa Landtwing Walter Bossart Alessandro Moretta Rocio Hassan Onur Boyman Gerald Niedobitek Henri-Jacques Delecluse Riccarda Capaul Christian Münz |
| spellingShingle |
Obinna Chijioke Anne Müller Regina Feederle Mario Henrique M. Barros Carsten Krieg Vanessa Emmel Emanuela Marcenaro Carol S. Leung Olga Antsiferova Vanessa Landtwing Walter Bossart Alessandro Moretta Rocio Hassan Onur Boyman Gerald Niedobitek Henri-Jacques Delecluse Riccarda Capaul Christian Münz Human Natural Killer Cells Prevent Infectious Mononucleosis Features by Targeting Lytic Epstein-Barr Virus Infection Cell Reports |
| author_facet |
Obinna Chijioke Anne Müller Regina Feederle Mario Henrique M. Barros Carsten Krieg Vanessa Emmel Emanuela Marcenaro Carol S. Leung Olga Antsiferova Vanessa Landtwing Walter Bossart Alessandro Moretta Rocio Hassan Onur Boyman Gerald Niedobitek Henri-Jacques Delecluse Riccarda Capaul Christian Münz |
| author_sort |
Obinna Chijioke |
| title |
Human Natural Killer Cells Prevent Infectious Mononucleosis Features by Targeting Lytic Epstein-Barr Virus Infection |
| title_short |
Human Natural Killer Cells Prevent Infectious Mononucleosis Features by Targeting Lytic Epstein-Barr Virus Infection |
| title_full |
Human Natural Killer Cells Prevent Infectious Mononucleosis Features by Targeting Lytic Epstein-Barr Virus Infection |
| title_fullStr |
Human Natural Killer Cells Prevent Infectious Mononucleosis Features by Targeting Lytic Epstein-Barr Virus Infection |
| title_full_unstemmed |
Human Natural Killer Cells Prevent Infectious Mononucleosis Features by Targeting Lytic Epstein-Barr Virus Infection |
| title_sort |
human natural killer cells prevent infectious mononucleosis features by targeting lytic epstein-barr virus infection |
| publisher |
Elsevier |
| series |
Cell Reports |
| issn |
2211-1247 |
| publishDate |
2013-12-01 |
| description |
Primary infection with the human oncogenic Epstein-Barr virus (EBV) can result in infectious mononucleosis (IM), a self-limiting disease caused by massive lymphocyte expansion that predisposes for the development of distinct EBV-associated lymphomas. Why some individuals experience this symptomatic primary EBV infection, whereas the majority acquires the virus asymptomatically, remains unclear. Using a mouse model with reconstituted human immune system components, we show that depletion of human natural killer (NK) cells enhances IM symptoms and promotes EBV-associated tumorigenesis mainly because of a loss of immune control over lytic EBV infection. These data suggest that failure of innate immune control by human NK cells augments symptomatic lytic EBV infection, which drives lymphocyte expansion and predisposes for EBV-associated malignancies.
|
| url |
http://www.sciencedirect.com/science/article/pii/S2211124713007250 |
| work_keys_str_mv |
AT obinnachijioke humannaturalkillercellspreventinfectiousmononucleosisfeaturesbytargetinglyticepsteinbarrvirusinfection AT annemuller humannaturalkillercellspreventinfectiousmononucleosisfeaturesbytargetinglyticepsteinbarrvirusinfection AT reginafeederle humannaturalkillercellspreventinfectiousmononucleosisfeaturesbytargetinglyticepsteinbarrvirusinfection AT mariohenriquembarros humannaturalkillercellspreventinfectiousmononucleosisfeaturesbytargetinglyticepsteinbarrvirusinfection AT carstenkrieg humannaturalkillercellspreventinfectiousmononucleosisfeaturesbytargetinglyticepsteinbarrvirusinfection AT vanessaemmel humannaturalkillercellspreventinfectiousmononucleosisfeaturesbytargetinglyticepsteinbarrvirusinfection AT emanuelamarcenaro humannaturalkillercellspreventinfectiousmononucleosisfeaturesbytargetinglyticepsteinbarrvirusinfection AT carolsleung humannaturalkillercellspreventinfectiousmononucleosisfeaturesbytargetinglyticepsteinbarrvirusinfection AT olgaantsiferova humannaturalkillercellspreventinfectiousmononucleosisfeaturesbytargetinglyticepsteinbarrvirusinfection AT vanessalandtwing humannaturalkillercellspreventinfectiousmononucleosisfeaturesbytargetinglyticepsteinbarrvirusinfection AT walterbossart humannaturalkillercellspreventinfectiousmononucleosisfeaturesbytargetinglyticepsteinbarrvirusinfection AT alessandromoretta humannaturalkillercellspreventinfectiousmononucleosisfeaturesbytargetinglyticepsteinbarrvirusinfection AT rociohassan humannaturalkillercellspreventinfectiousmononucleosisfeaturesbytargetinglyticepsteinbarrvirusinfection AT onurboyman humannaturalkillercellspreventinfectiousmononucleosisfeaturesbytargetinglyticepsteinbarrvirusinfection AT geraldniedobitek humannaturalkillercellspreventinfectiousmononucleosisfeaturesbytargetinglyticepsteinbarrvirusinfection AT henrijacquesdelecluse humannaturalkillercellspreventinfectiousmononucleosisfeaturesbytargetinglyticepsteinbarrvirusinfection AT riccardacapaul humannaturalkillercellspreventinfectiousmononucleosisfeaturesbytargetinglyticepsteinbarrvirusinfection AT christianmunz humannaturalkillercellspreventinfectiousmononucleosisfeaturesbytargetinglyticepsteinbarrvirusinfection |
| _version_ |
1725178730120216576 |