eIF4E S209 phosphorylation licenses myc- and stress-driven oncogenesis

eIF4E S209 phosphorylation licenses myc- and stress-driven oncogenesis

To better understand a role of eIF4E S209 in oncogenic translation, we generated EIF4ES209A/+ heterozygous knockin (4EKI) HCT 116 human colorectal cancer (CRC) cells. 4EKI had little impact on total eIF4E levels, cap binding or global translation, but markedly reduced HCT 116 cell growth in spheroid...

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Bibliographic Details
Main Authors: Hang Ruan, Xiangyun Li, Xiang Xu, Brian J Leibowitz, Jingshan Tong, Lujia Chen, Luoquan Ao, Wei Xing, Jianhua Luo, Yanping Yu, Robert E Schoen, Nahum Sonenberg, Xinghua Lu, Lin Zhang, Jian Yu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-11-01
Series:eLife
Subjects:
eIF4E S209
Myc
KRAS
the integrated stress response
glutamine
colon cancer
Online Access:https://elifesciences.org/articles/60151

Internet

https://elifesciences.org/articles/60151

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