The Orphan Nuclear Receptor TLX Represses Hes1 Expression, Thereby Affecting NOTCH Signaling and Lineage Progression in the Adult SEZ

Summary: In the adult subependymal zone (SEZ), neural stem cells (NSCs) apically contacting the lateral ventricle on activation generate progenitors proliferating at the niche basal side. We here show that Tailless (TLX) coordinates NSC activation and basal progenitor proliferation by repressing the...

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Bibliographic Details
Main Authors: Inma Luque-Molina, Yan Shi, Yomn Abdullah, Sara Monaco, Gabriele Hölzl-Wenig, Claudia Mandl, Francesca Ciccolini
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671119301717