Rad52 Oligomeric N-Terminal Domain Stabilizes Rad51 Nucleoprotein Filaments and Contributes to Their Protection against Srs2

Rad52 Oligomeric N-Terminal Domain Stabilizes Rad51 Nucleoprotein Filaments and Contributes to Their Protection against Srs2

Homologous recombination (HR) depends on the formation of a nucleoprotein filament of the recombinase Rad51 to scan the genome and invade the homologous sequence used as a template for DNA repair synthesis. Therefore, HR is highly accurate and crucial for genome stability. Rad51 filament formation i...

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Bibliographic Details
Main Authors: Emilie Ma, Laurent Maloisel, Léa Le Falher, Raphaël Guérois, Eric Coïc
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cells
Subjects:
genome stability
DNA repair
Homologous Recombination
Rad52
Rad51
Srs2
Online Access:https://www.mdpi.com/2073-4409/10/6/1467

Internet

https://www.mdpi.com/2073-4409/10/6/1467

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