A comparison of methods to generate adaptive reference ranges in longitudinal monitoring.

In a clinical setting, biomarkers are typically measured and evaluated as biological indicators of a physiological state. Population based reference ranges, known as 'static' or 'normal' reference ranges, are often used as a tool to classify a biomarker value for an individual as...

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Bibliographic Details
Main Authors: Davood Roshan, John Ferguson, Charles R Pedlar, Andrew Simpkin, William Wyns, Frank Sullivan, John Newell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0247338