Inhibition of Streptococcus mutans polysaccharide synthesis by molecules targeting glycosyltransferase activity
Glycosyltransferase (Gtf) is one of the crucial virulence factors of Streptococcus mutans, a major etiological pathogen of dental caries. All the available evidence indicates that extracellular polysaccharide, particularly glucans produced by S. mutans Gtfs, contribute to the cariogenicity of dental...
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doaj-814e92eb8ab044ef8f7fde5333747c202020-11-24T22:15:21ZengTaylor & Francis GroupJournal of Oral Microbiology2000-22972016-04-01801910.3402/jom.v8.3109531095Inhibition of Streptococcus mutans polysaccharide synthesis by molecules targeting glycosyltransferase activityZhi Ren0Lulu Chen1Jiyao Li2Yuqing Li3 State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, People's Republic of China State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, People's Republic of China State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, People's Republic of China State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, People's Republic of ChinaGlycosyltransferase (Gtf) is one of the crucial virulence factors of Streptococcus mutans, a major etiological pathogen of dental caries. All the available evidence indicates that extracellular polysaccharide, particularly glucans produced by S. mutans Gtfs, contribute to the cariogenicity of dental biofilms. Therefore, inhibition of Gtf activity and the consequential polysaccharide synthesis may impair the virulence of cariogenic biofilms, which could be an alternative strategy to prevent the biofilm-related disease. Up to now, many Gtf inhibitors have been recognized in natural products, which remain the major and largely unexplored source of Gtf inhibitors. These include catechin-based polyphenols, flavonoids, proanthocyanidin oligomers, polymeric polyphenols, and some other plant-derived compounds. Metal ions, oxidizing agents, and some other synthetic compounds represent another source of Gtf inhibitors, with some novel molecules either discovered by structure-based virtual screening or synthesized based on key structures of known inhibitors as templates. Antibodies that inhibit one or more Gtfs have also been developed as topical agents. Although many agents have been shown to possess potent inhibitory activity against glucan synthesis by Gtfs, bacterial cell adherence, and caries development in animal models, much research remains to be performed to find out their mechanism of action, biological safety, cariostatic efficacies, and overall influence on the entire oral community. As a strategy to inhibit the virulence of cariogenic microbes rather than eradicate them from the microbial community, Gtf inhibition represents an approach of great potential to prevent dental caries.http://www.journaloforalmicrobiology.net/index.php/jom/article/view/31095/46128inhibitorglycosyltransferaseS. mutansdental caries |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhi Ren Lulu Chen Jiyao Li Yuqing Li |
spellingShingle |
Zhi Ren Lulu Chen Jiyao Li Yuqing Li Inhibition of Streptococcus mutans polysaccharide synthesis by molecules targeting glycosyltransferase activity Journal of Oral Microbiology inhibitor glycosyltransferase S. mutans dental caries |
author_facet |
Zhi Ren Lulu Chen Jiyao Li Yuqing Li |
author_sort |
Zhi Ren |
title |
Inhibition of Streptococcus mutans polysaccharide synthesis by molecules targeting glycosyltransferase activity |
title_short |
Inhibition of Streptococcus mutans polysaccharide synthesis by molecules targeting glycosyltransferase activity |
title_full |
Inhibition of Streptococcus mutans polysaccharide synthesis by molecules targeting glycosyltransferase activity |
title_fullStr |
Inhibition of Streptococcus mutans polysaccharide synthesis by molecules targeting glycosyltransferase activity |
title_full_unstemmed |
Inhibition of Streptococcus mutans polysaccharide synthesis by molecules targeting glycosyltransferase activity |
title_sort |
inhibition of streptococcus mutans polysaccharide synthesis by molecules targeting glycosyltransferase activity |
publisher |
Taylor & Francis Group |
series |
Journal of Oral Microbiology |
issn |
2000-2297 |
publishDate |
2016-04-01 |
description |
Glycosyltransferase (Gtf) is one of the crucial virulence factors of Streptococcus mutans, a major etiological pathogen of dental caries. All the available evidence indicates that extracellular polysaccharide, particularly glucans produced by S. mutans Gtfs, contribute to the cariogenicity of dental biofilms. Therefore, inhibition of Gtf activity and the consequential polysaccharide synthesis may impair the virulence of cariogenic biofilms, which could be an alternative strategy to prevent the biofilm-related disease. Up to now, many Gtf inhibitors have been recognized in natural products, which remain the major and largely unexplored source of Gtf inhibitors. These include catechin-based polyphenols, flavonoids, proanthocyanidin oligomers, polymeric polyphenols, and some other plant-derived compounds. Metal ions, oxidizing agents, and some other synthetic compounds represent another source of Gtf inhibitors, with some novel molecules either discovered by structure-based virtual screening or synthesized based on key structures of known inhibitors as templates. Antibodies that inhibit one or more Gtfs have also been developed as topical agents. Although many agents have been shown to possess potent inhibitory activity against glucan synthesis by Gtfs, bacterial cell adherence, and caries development in animal models, much research remains to be performed to find out their mechanism of action, biological safety, cariostatic efficacies, and overall influence on the entire oral community. As a strategy to inhibit the virulence of cariogenic microbes rather than eradicate them from the microbial community, Gtf inhibition represents an approach of great potential to prevent dental caries. |
topic |
inhibitor glycosyltransferase S. mutans dental caries |
url |
http://www.journaloforalmicrobiology.net/index.php/jom/article/view/31095/46128 |
work_keys_str_mv |
AT zhiren inhibitionofstreptococcusmutanspolysaccharidesynthesisbymoleculestargetingglycosyltransferaseactivity AT luluchen inhibitionofstreptococcusmutanspolysaccharidesynthesisbymoleculestargetingglycosyltransferaseactivity AT jiyaoli inhibitionofstreptococcusmutanspolysaccharidesynthesisbymoleculestargetingglycosyltransferaseactivity AT yuqingli inhibitionofstreptococcusmutanspolysaccharidesynthesisbymoleculestargetingglycosyltransferaseactivity |
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