In vivo and in vitro studies suggest a possible involvement of HPV infection in the early stage of breast carcinogenesis via APOBEC3B induction.

High prevalence of infection with high-risk human papilloma virus (HPV) ranging from 25 to 100% (average 31%) was observed in breast cancer (BC) patients in Singapore using novel DNA chip technology. Early stage of BC demonstrated higher HPV positivity, and BC positive for estrogen receptor (ER) sho...

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Main Authors: Kenji Ohba, Koji Ichiyama, Misako Yajima, Nobuhiro Gemma, Masaru Nikaido, Qingqing Wu, PeiPei Chong, Seiichiro Mori, Rain Yamamoto, John Eu Li Wong, Naoki Yamamoto
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4032256?pdf=render