Alzheimer-associated cerebrospinal fluid fragments of neurogranin are generated by Calpain-1 and prolyl endopeptidase

Alzheimer-associated cerebrospinal fluid fragments of neurogranin are generated by Calpain-1 and prolyl endopeptidase

Abstract Background Neurogranin (Ng) is a small 7.6 kDa postsynaptic protein that has been detected at elevated concentrations in cerebrospinal fluid (CSF) of patients with Alzheimer’s disease (AD), both as a full-length molecule and as fragments from its C-terminal half. Ng is involved in postsynap...

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Bibliographic Details
Main Authors: Bruno Becker, Faisal Hayat Nazir, Gunnar Brinkmalm, Elena Camporesi, Hlin Kvartsberg, Erik Portelius, Martina Boström, Marie Kalm, Kina Höglund, Maria Olsson, Henrik Zetterberg, Kaj Blennow
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Molecular Neurodegeneration
Subjects:
Neurogranin
Calpain
Prolyl endopeptidase
Postsynaptic protein
IQ domain
Biomarker
Online Access:http://link.springer.com/article/10.1186/s13024-018-0279-z

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http://link.springer.com/article/10.1186/s13024-018-0279-z

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