From Inflammation to Cutaneous Repair: Topical Application of Lupeol Improves Skin Wound Healing in Rats by Modulating the Cytokine Levels, NF-κB, Ki-67, Growth Factor Expression, and Distribution of Collagen Fibers

From Inflammation to Cutaneous Repair: Topical Application of Lupeol Improves Skin Wound Healing in Rats by Modulating the Cytokine Levels, NF-κB, Ki-67, Growth Factor Expression, and Distribution of Collagen Fibers

Skin wound healing is a highly complex event that involves different mediators at the cellular and molecular level. Lupeol has been reported to possess different biological activities, such as anti-inflammatory, antioxidant, antidiabetic, and in vitro wound healing properties, which motivated us to...

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Bibliographic Details
Main Authors: Fernando Pereira Beserra, Lucas Fernando Sérgio Gushiken, Ana Júlia Vieira, Danilo Augusto Bérgamo, Patrícia Luísa Bérgamo, Mariana Oliveira de Souza, Carlos Alberto Hussni, Regina Kiomi Takahira, Rafael Henrique Nóbrega, Emanuel Ricardo Monteiro Martinez, Christopher John Jackson, Gabriela Lemos de Azevedo Maia, Ariane Leite Rozza, Cláudia Helena Pellizzon
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
cutaneous wound healing
natural product
triterpene
lupeol
skin regeneration
Online Access:https://www.mdpi.com/1422-0067/21/14/4952

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https://www.mdpi.com/1422-0067/21/14/4952

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